Armstrong D R, Neill K H, Crain B J, Nadler J V
Department of Pharmacology, Duke University Medical Center, Durham, NC 27710.
Brain Res. 1989 Jan 2;476(1):174-8. doi: 10.1016/0006-8993(89)91554-0.
EEG was continuously recorded from Mongolian gerbils for 4 days after transient bilateral forebrain ischemia, to determine whether ischemic brain damage in this species is necessarily associated with seizures. Gerbils were chronically implanted with EEG recording electrodes in hippocampal area CA1, striatum and frontal neocortex and were subjected to a 5-10 min occlusion of both common carotid arteries. During the first few hours after the occlusion, the EEG was dominated by slow waves similar to those recorded from human brain after a damaging episode of cerebral ischemia. Amplitudes of the hippocampal and striatal EEG declined markedly with time, presumably as a result of neuronal degeneration. Ictal activity was never recorded, even from animals that suffered extreme damage to the hippocampal formation and striatum. Therefore ischemic brain damage in the gerbil does not result from seizure activity.
在短暂性双侧前脑缺血后，对蒙古沙鼠连续4天进行脑电图（EEG）记录，以确定该物种的缺血性脑损伤是否必然与癫痫发作相关。沙鼠被长期植入位于海马体CA1区、纹状体和额叶新皮质的EEG记录电极，并对双侧颈总动脉进行5 - 10分钟的阻断。在阻断后的最初几个小时内，EEG以慢波为主，类似于人脑在经历脑缺血损伤发作后所记录到的慢波。海马体和纹状体EEG的振幅随时间显著下降，推测是神经元变性的结果。即使是海马结构和纹状体遭受极端损伤的动物，也从未记录到发作期活动。因此，沙鼠的缺血性脑损伤并非由癫痫活动引起。
