Prindull G
Blut. 1979 Oct;39(4):293-300. doi: 10.1007/BF01013224.
Osteogenic sarcoma may be treated effectively by radical surgical removal of the primary tumor and combined chemotherapy, including Adriamycin and high dose Methotrexate. In order to render any protocol a safe procedure, strict precautions are required to avoid drug toxicity. We present a protocol, "COSS 77", presently employed in several university hospitals of West Germany and Austria. Final results concerning long term prognosis and long term side effects are not yet available.
骨肉瘤可通过根治性手术切除原发肿瘤并联合化疗（包括阿霉素和大剂量甲氨蝶呤）进行有效治疗。为使任何治疗方案成为安全的程序，需要严格预防措施以避免药物毒性。我们介绍一种目前在西德和奥地利的几家大学医院中使用的“COSS 77”方案。关于长期预后和长期副作用的最终结果尚无定论。
