Joensuu H
Department of Radiotherapy, University Central Hospital, Turku, Finland.
Chest. 1989 Feb;95(2):388-90. doi: 10.1378/chest.95.2.388.
Forty-seven patients younger than 40 years at the time of the diagnosis, and irradiated to the mediastinum for Hodgkin's disease at Turku University Central Hospital from 1977 to 1982, were regularly followed for 56 to 127 months after therapy. Two patients developed an acute myocardial infarction ten and 50 months after cardiac irradiation at the age of only 28 and 24 years, respectively. None of the patients died from lymphoma within five years from the diagnosis, but one of the infarctions was eventually fatal. Since acute myocardial infarction is rare in this age group, the result suggests strongly that prior cardiac irradiation is a risk factor for acute myocardial infarction. The possibility of radiation-induced myocardial infarction should be taken into account both in treatment planning and follow-up of patients with Hodgkin's disease.
47例在诊断时年龄小于40岁、于1977年至1982年在图尔库大学中心医院因霍奇金病接受纵隔照射的患者，在治疗后接受了56至127个月的定期随访。两名患者分别在心脏照射后10个月和50个月时发生急性心肌梗死，当时年龄仅为28岁和24岁。所有患者在诊断后5年内均未死于淋巴瘤，但其中一次心肌梗死最终导致死亡。由于急性心肌梗死在该年龄组中罕见，该结果强烈提示先前的心脏照射是急性心肌梗死的一个危险因素。在霍奇金病患者的治疗计划和随访中均应考虑辐射诱发心肌梗死的可能性。
