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Y形支架联合碘-125粒子链治疗门静脉分支肿瘤血栓形成的肝细胞癌:1例报告

Y-configuration stent combined with iodine-125 seeds strand for the treatment of hepatocellular carcinoma with tumor thrombosis in portal vein branches: A case report.

作者信息

Tan Tan, Xiao Yudong, Zhou Shunke, Ma Cong, Zhang Zishu

机构信息

Department of Radiology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, P.R. China.

出版信息

Medicine (Baltimore). 2017 Nov;96(46):e8660. doi: 10.1097/MD.0000000000008660.

DOI:10.1097/MD.0000000000008660
PMID:29145293
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5704838/
Abstract

RATIONALE

Currently, the treatment of hepatocellular carcinoma (HCC) associated with portal vein tumor thrombosis (PVTT) is a challenge. Percutaneous puncture endovascular placement of iodine-125 (I) seeds strand and stent is reported to treat HCC with tumor thrombus effectively. However, it is proved to be only suitable for the main portal vein (MPV) thrombus.

PATIENT CONCERNS

A 42-year-old male patient was referred to our institution after experiencing right upper abdominal distention without abdominal pain, nausea, or vomiting for 2 weeks. The patient had a history of hepatitis B virus infection over a 20 year period.

DIAGNOSIS

After a full evaluation, the patient was diagnosed with primary HCC with a tumor thrombus in both main and branch portal veins.

INTERVENTIONS

We used a Y-configuration stent combined with I seeds strand to treat the tumor thrombus in both main and branch portal veins.

OUTCOMES

The patient's liver function and the stent patency period were improved. More importantly, the patient had an acceptable survival time.

LESSONS

A Y-configuration stent makes it possible to treat tumor thrombosis in portal vein branches (PVBs). However, the long-term curative effects of Y-configuration stents need to be verified.

摘要

理论依据

目前,肝细胞癌(HCC)合并门静脉癌栓(PVTT)的治疗是一项挑战。据报道,经皮穿刺血管内植入碘-125(I)粒子链和支架可有效治疗伴有肿瘤血栓的HCC。然而,事实证明它仅适用于门静脉主干(MPV)血栓。

患者情况

一名42岁男性患者因右上腹腹胀2周,无腹痛、恶心或呕吐前来我院就诊。该患者有20年的乙型肝炎病毒感染史。

诊断

经过全面评估,患者被诊断为原发性HCC,门静脉主干和分支均有肿瘤血栓。

干预措施

我们采用Y形支架联合I粒子链治疗门静脉主干和分支的肿瘤血栓。

结果

患者的肝功能和支架通畅时间得到改善。更重要的是,患者有可接受的生存时间。

经验教训

Y形支架使治疗门静脉分支(PVB)的肿瘤血栓成为可能。然而,Y形支架的长期疗效有待验证。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/63d1/5704838/a4ba3de6412e/medi-96-e8660-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/63d1/5704838/8b831864a8e3/medi-96-e8660-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/63d1/5704838/ca7534b4d1f3/medi-96-e8660-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/63d1/5704838/0e3c555b2750/medi-96-e8660-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/63d1/5704838/a4ba3de6412e/medi-96-e8660-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/63d1/5704838/8b831864a8e3/medi-96-e8660-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/63d1/5704838/ca7534b4d1f3/medi-96-e8660-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/63d1/5704838/0e3c555b2750/medi-96-e8660-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/63d1/5704838/a4ba3de6412e/medi-96-e8660-g004.jpg

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本文引用的文献

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Treatment of hepatocellular carcinoma with portal venous tumor thrombosis: A comprehensive review.门静脉癌栓型肝细胞癌的治疗:综述
World J Gastroenterol. 2016 Jan 7;22(1):407-16. doi: 10.3748/wjg.v22.i1.407.
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Endovascular brachytherapy combined with stent placement and TACE for treatment of HCC with main portal vein tumor thrombus.血管内近距离放射治疗联合支架置入及经动脉化疗栓塞术治疗伴有门静脉主干癌栓的肝癌
Hepatol Int. 2016 Jan;10(1):185-95. doi: 10.1007/s12072-015-9663-8. Epub 2015 Sep 4.
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Efficacy of therapy for hepatocellular carcinoma with portal vein tumor thrombus: chemoembolization and stent combined with iodine-125 seed.
Stents combined with iodine-125 implantation to treat main portal vein tumor thrombus.支架联合碘-125植入治疗门静脉主干肿瘤血栓。
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经导管化疗栓塞和支架联合碘-125 粒子治疗合并门静脉癌栓的肝细胞癌的疗效
Cancer Biol Ther. 2011 Nov 15;12(10):865-71. doi: 10.4161/cbt.12.10.17676.
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Hepatocellular carcinoma with portal vein tumor thrombosis: Improved treatment outcomes with external beam radiation therapy.肝细胞癌伴门静脉癌栓:外照射放疗改善治疗效果。
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Endovascular placement of iodine-125 seed strand and stent combined with chemoembolization for treatment of hepatocellular carcinoma with tumor thrombus in main portal vein.碘 125 粒子条和支架的血管内放置联合化疗栓塞治疗主门静脉癌栓的肝细胞癌。
J Vasc Interv Radiol. 2011 Apr;22(4):479-89. doi: 10.1016/j.jvir.2010.11.029.
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Management of hepatocellular carcinoma: an update.肝细胞癌的管理:最新进展
Hepatology. 2011 Mar;53(3):1020-2. doi: 10.1002/hep.24199.
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Hepatocellular carcinoma presenting as an incidental isolated malignant portal vein thrombosis.肝细胞癌表现为偶然发现的孤立性恶性门静脉血栓形成。
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Sorafenib in advanced hepatocellular carcinoma.索拉非尼用于晚期肝细胞癌
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Treatment of hepatocellular carcinoma accompanied by portal vein tumor thrombus.伴有门静脉癌栓的肝细胞癌的治疗
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