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上睑下垂作为糖尿病性动眼神经上支麻痹的唯一表现:1例病例报告。

Ptosis as the only manifestation of diabetic superior division oculomotor nerve palsy: A case report.

作者信息

Chou Ping-Yin, Wu Kun-Han, Huang Poyin

机构信息

aDepartment of Neurology, Kaohsiung Medical University Hospital, Kaohsiung Medical University bDepartment of Neurology, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung Medical University, Kaohsiung cPhD Program in Translational Medicine, Kaohsiung Medical University and Academia Sinica dDepartment of Neurology, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.

出版信息

Medicine (Baltimore). 2017 Nov;96(46):e8739. doi: 10.1097/MD.0000000000008739.

Abstract

RATIONALE

Diabetic oculomotor nerve palsies, also called ischemic third nerve palsies, are the most common etiologic subset of oculomotor nerve palsy in adults. Diabetic oculomotor nerve palsies typically present with ptosis and diplopia, but pupillary function is often spared. The oculomotor nerve separates into superior division and inferior division, with the superior division innervating the superior rectus and levator palpebrae superioris. The diabetic oculomotor nerve palsy may affect isolated superior or inferior division of the oculomotor nerve, but diplopia usually exists.

PATIENT CONCERNS

A 56-year-old female was admitted to our hospital for acute onset right upper lid ptosis. The patient denied diplopia or other new focal neurologic symptoms. The neurological examination revealed ptosis of the right upper eyelid only, and other neurological examination revealed negative findings.

DIAGNOSES

The diagnosis of diabetes-associated oculomotor nerve palsy was made, with acute ptosis as its only manifestation.

INTERVENTIONS

We controlled her blood sugar aggressively with insulin.

OUTCOMES

After the hyperglycemia improved, the right side ptosis recovered partially within one week.

LESSONS

From this case, we suggest that when evaluating patients with acute onset ptosis as the only manifestation, diabetic-vasculopathic neuropathy should be considered. This case also implies that the most interior portion of the third cranial nerve may consist of nerve fibers mainly innervating the levator palpebrae superioris.

摘要

理论依据

糖尿病性动眼神经麻痹,也称为缺血性动眼神经麻痹,是成人动眼神经麻痹最常见的病因亚型。糖尿病性动眼神经麻痹通常表现为上睑下垂和复视,但瞳孔功能通常不受影响。动眼神经分为上支和下支,上支支配上直肌和上睑提肌。糖尿病性动眼神经麻痹可能影响动眼神经的孤立上支或下支,但通常存在复视。

患者情况

一名56岁女性因急性发作的右上睑下垂入院。患者否认复视或其他新的局灶性神经症状。神经系统检查仅发现右上睑下垂,其他神经系统检查结果均为阴性。

诊断

诊断为糖尿病相关性动眼神经麻痹,仅以急性上睑下垂为唯一表现。

干预措施

我们用胰岛素积极控制她的血糖。

结果

高血糖改善后,右侧上睑下垂在一周内部分恢复。

经验教训

从这个病例中,我们建议在评估以急性上睑下垂为唯一表现的患者时,应考虑糖尿病性血管病变性神经病变。这个病例还表明,第三脑神经的最内侧部分可能主要由支配上睑提肌的神经纤维组成。

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引用本文的文献

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本文引用的文献

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Ophthalmoplegia in diabetes mellitus: a retrospective study.糖尿病性眼肌麻痹:一项回顾性研究。
Acta Diabetol. 2009 Mar;46(1):23-6. doi: 10.1007/s00592-008-0053-8. Epub 2008 Aug 29.
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Diabetic neuropathy: mechanisms to management.糖尿病神经病变:从发病机制到治疗方法
Pharmacol Ther. 2008 Oct;120(1):1-34. doi: 10.1016/j.pharmthera.2008.05.005. Epub 2008 Jun 13.
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Pupil involvement in patients with diabetes-associated oculomotor nerve palsy.
Arch Ophthalmol. 1998 Jun;116(6):723-7. doi: 10.1001/archopht.116.6.723.

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