He Fei, Xie Jing-Xian, Liu Chun-Lan, Xiong Wei-Min, Xu Qiu-Ping, Liu Zhi-Qiang, Lin Tao, Xiao Ren-Dong, Li Xu, Cai Lin
aDepartment of Epidemiology bFujian Provincial Key Laboratory of Environment Factors and Cancer, School of Public Health, Fujian Medical University, Fuzhou cState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, Xiamen University, Xiamen, Fujian dDepartment of Obstetrics and Gynecology, Xiamen Maternity and Child Health Care Hospital eDepartment of Thoracic Surgery, The First Affiliated Hospital of Fujian Medical University fFujian Provincial Key Laboratory of Tumor Microbiology, Fujian Medical University, Fuzhou, China.
Medicine (Baltimore). 2017 Nov;96(46):e8816. doi: 10.1097/MD.0000000000008816.
The aim of this study was to investigate the association of menstrual and reproductive factors with risk of lung cancer in women. Potential etiological clues related to lung cancer in women are identified to inform preventive strategies.Case-control study of 477 newly diagnosed women with lung cancer and 479 age-matched (±2 years) controls. Data on menstrual and reproductive factors and history of oral contraceptive use were obtained on personal interviews using a structured questionnaire. Risk factors were analyzed by unconditional logistic regression analysis.Maternal age ≥25 years at first birth appeared to protect against female lung cancer [odds ratios (ORs): 0.511, 95% confidence interval (CI), 0.376-0.693]. Age at menopause > 50 years and use of contraceptives was associated with an increased risk of lung cancer in women (OR: 1.471, 95% CI, 1.021-2.119 and OR: 1.844, 95% CI: 1.111-3.061, respectively). Age ≥13 years at menarche was associated with a decreased risk of lung adenocarcinoma (OR: 0.563, 95% CI, 0.317-0.997). There was significant heterogeneity in the levels of cooking oil fume (COF) exposure (Pheterogeneity = .015). Higher levels of exposure to passive smoking, COF, and lack of tea intake were associated with an increased risk of lung cancer.Menstrual and reproductive factors are considered to play a role in the development of lung cancer in women. Exposure to passive smoking, COF, and lack of tea intake appeared to significantly modify the relationship.
本研究旨在调查月经和生殖因素与女性肺癌风险之间的关联。识别与女性肺癌相关的潜在病因线索，为预防策略提供依据。对477名新诊断的女性肺癌患者和479名年龄匹配（±2岁）的对照进行病例对照研究。通过使用结构化问卷进行个人访谈，获取月经和生殖因素以及口服避孕药使用史的数据。通过无条件逻辑回归分析对危险因素进行分析。首次生育时母亲年龄≥25岁似乎可预防女性肺癌[比值比（OR）：0.511，95%置信区间（CI），0.376 - 0.693]。绝经年龄>50岁和使用避孕药与女性肺癌风险增加相关（OR分别为：1.471，95% CI，1.021 - 2.119；OR为：1.844，95% CI：1.111 - 3.061）。初潮年龄≥13岁与肺腺癌风险降低相关（OR：0.563，95% CI，0.317 - 0.997）。食用油油烟（COF）暴露水平存在显著异质性（P异质性 = 0.015）。被动吸烟、COF暴露水平较高以及缺乏饮茶与肺癌风险增加相关。月经和生殖因素被认为在女性肺癌的发生中起作用。被动吸烟、COF暴露和缺乏饮茶似乎显著改变了这种关系。
