He Baochang, Chen Fa, Yan Lingjun, Huang Jiangfeng, Liu Fangping, Qiu Yu, Lin Lisong, Zhang Zuofeng, Cai Lin
a Department of Epidemiology and Health Statistics, School of Public Health , Fujian Medical University , Fujian , PR China ;
b Department of Stomatology , First Affiliated Hospital of Fujian Medical University , Fujian , PR China ;
Acta Otolaryngol. 2016 Oct;136(10):1074-8. doi: 10.1080/00016489.2016.1185539. Epub 2016 May 25.
Passive smoking and COF exposure are independent risk factors for oral cancer in Chinese women, with the multiplicative interactions from combined exposures. Avoiding exposure to environmental tobacco smoke and COF may contribute to the prevention of oral cancer in Chinese women.
To evaluate the independent and joint effects of passive smoking and cooking oil fumes (COF) on oral cancer in Chinese women.
A case-control study was performed including 238 female patients with pathologically confirmed oral cancer and 470 controls as age-matched controls. Face-to-face interviews were conducted based on a structured questionnaire. The effects of passive smoking and COF exposure were analyzed using non-conditional logistic regression models.
Passive smoking significantly increased the risk of oral cancer in Chinese women: adjusted ORs were 2.12 (95% CI = 1.11-4.07) for those only exposed before age 18, 1.52 (95% CI = 1.01-2.31) for those only exposed after age 18, and 2.38 (95% CI = 1.47-3.85) for those both exposed before and after age 18. In addition, COF exposure was significantly associated with a risk of oral cancer (adjusted ORs were 1.69 (95% CI = 1.03-2.78) for light exposure and 2.06 (95% CI = 1.21-3.50) for heavy exposure). Furthermore, there was a significantly multiplicative interaction between passive smoking and COF for oral cancer.
被动吸烟和接触烹饪油烟是中国女性患口腔癌的独立危险因素，且二者联合暴露存在相乘交互作用。避免接触环境烟草烟雾和烹饪油烟可能有助于预防中国女性患口腔癌。
评估被动吸烟和烹饪油烟（COF）对中国女性口腔癌的独立及联合作用。
开展一项病例对照研究，纳入238例经病理确诊的女性口腔癌患者以及470例年龄匹配的对照。基于结构化问卷进行面对面访谈。采用非条件逻辑回归模型分析被动吸烟和接触烹饪油烟的影响。
被动吸烟显著增加中国女性患口腔癌的风险：仅在18岁前暴露者的调整比值比为2.12（95%置信区间=1.11 - 4.07），仅在18岁后暴露者为1.52（95%置信区间=1.01 - 2.31），18岁前后均暴露者为2.38（95%置信区间=1.47 - 3.85）。此外，接触烹饪油烟与口腔癌风险显著相关（轻度暴露的调整比值比为1.69（95%置信区间=1.03 - 2.78），重度暴露为2.06（95%置信区间=1.21 - 3.50））。此外，被动吸烟和接触烹饪油烟对口腔癌存在显著的相乘交互作用。
