Ito Hiroya, Takahashi Sayaka, Asai Tetsuo, Tamura Yutaka, Yamamoto Koshi
The National Institute of Animal Health, National Agriculture and Food Research Organization, Tsukuba, Ibaraki, Japan (Ito).
Zen-Noh Institute of Animal Health, Sakura, Chiba, Japan (Takahashi).
J Vet Diagn Invest. 2018 Jan;30(1):172-174. doi: 10.1177/1040638717742436. Epub 2017 Nov 16.
An atypical urease-negative mutant of Actinobacillus pleuropneumoniae serovar 2 was isolated in Japan. Nucleotide sequence analysis of the urease gene cluster revealed that the insertion of a short DNA sequence into the cbiM gene was responsible for the urease-negative activity of the mutant. Veterinary diagnostic laboratories should be watchful for the presence of aberrant urease-negative A. pleuropneumoniae isolates.
在日本分离出了胸膜肺炎放线杆菌2型的一株非典型脲酶阴性突变株。脲酶基因簇的核苷酸序列分析表明，cbiM基因中插入一段短DNA序列是该突变株脲酶阴性活性的原因。兽医诊断实验室应警惕出现异常的脲酶阴性胸膜肺炎放线杆菌分离株。
