Usman Rashid, Jamil Muhammad, Naveed Muhammad
Department of Vascular Surgery, Combined Military Hospital, Lahore Cantt, Pakistan.
Department of Vascular Surgery, Combined Military Hospital, Peshawar Cantt, Pakistan.
Ann Vasc Dis. 2017 Sep 25;10(3):205-10. doi: 10.3400/avd.oa.17-00016.
: To study the association between a high preoperative neutrophil lymphocyte ratio (NLR) and red cell distribution width (RDW) with arteriovenous fistula (AVF) failure, as well as to determine the cut-off values in a South Asian population. : A total of 150 consecutive patients with a failed fistula who presented in the Department of Vascular Surgery between January 2014 and January 2016. Patients fulfilling the inclusion criteria were selected as defined as Case. They were compared with 150 patients who had matured fistulae (Control). : A significant difference was found between the Case and Control groups in mean preoperative NLR (3.3±0.5 versus 2.2±0.9, P value=0.011) and RDW (15.9±2.9 versus 13.6±1.1%, P value of 0.02), respectively. Multivariate analysis revealed that NLR (Odds Ratios (OR) 1.39; 95% Confidence Intervals (CI) 1.02 to 2.08; P<0.001) and RDW (OR 1.39; 95%CI 1.11 to 1.69; P<0.001) were strong independent predictors of AVF failure. A receiver operating characteristic curve analysis showed a cut-off value of 2.65 (specificity 80%, sensitivity 98%) and 15.1 (specificity 79%, sensitivity 98%) for NLR and RDW, respectively. : Increased preoperative NLR and RDW were associated with a high rate of AVF failure in a South Asian population.
研究术前高中性粒细胞淋巴细胞比值（NLR）和红细胞分布宽度（RDW）与动静脉内瘘（AVF）失败之间的关联，并确定南亚人群中的临界值。：2014年1月至2016年1月期间，血管外科共收治150例连续的内瘘失败患者。符合纳入标准的患者被选为病例组。将他们与150例内瘘成熟的患者（对照组）进行比较。：病例组和对照组术前平均NLR（3.3±0.5对2.2±0.9，P值=0.011）和RDW（15.9±2.9对13.6±1.1%，P值为0.02）分别存在显著差异。多变量分析显示，NLR（比值比（OR）1.39；95%置信区间（CI）1.02至2.08；P<0.001）和RDW（OR 1.39；95%CI 1.11至1.69；P<0.001）是AVF失败的强有力独立预测因素。受试者工作特征曲线分析显示，NLR和RDW的临界值分别为2.65（特异性80%，敏感性98%）和15.1（特异性79%，敏感性98%）。：术前NLR和RDW升高与南亚人群中AVF的高失败率相关。
