新诊断的HER2阳性乳腺癌的巨大脑转移灶对一线曲妥珠单抗化疗的完全放射学缓解
Complete Radiologic Response of Bulky Cerebral Metastases From Newly Diagnosed HER2-Positive Breast Cancer to Upfront Trastuzumab-Based Chemotherapy.
作者信息
Brungs Daniel, Sze Victor, Emmett Louise, Epstein Richard J
机构信息
Departments of Oncology, St Vincent's Hospital, Sydney, Australia.
Medical Imaging, St Vincent's Hospital, Sydney, Australia.
出版信息
World J Oncol. 2013 Apr;4(2):122-125. doi: 10.4021/wjon639w. Epub 2013 May 6.
Abstract
The blood-brain barrier is traditionally regarded as an insurmountable obstacle to the effective drug therapy of brain metastases from solid tumors. Here we describe a striking case of complete radiologic response to chemotherapy, and propose that the critical success factors include the large tumor size, HER2-positivity, and concomitant use of trastuzumab.
摘要
血脑屏障传统上被视为实体瘤脑转移有效药物治疗难以逾越的障碍。在此，我们描述了一例对化疗有显著放射学反应的惊人病例，并提出关键的成功因素包括肿瘤体积大、HER2阳性以及同时使用曲妥珠单抗。
Zotero 插件