Singh Shantanu, Mack David, Dookhan Dianne, Jyotimallika Juthika
Duke LPMP Medical Center, North Carolina, USA.
World J Oncol. 2013 Oct;4(4-5):210-213. doi: 10.4021/wjon704w. Epub 2013 Sep 27.
Uterine papillary serous carcinoma (UPSC) is an aggressive variant of endometrial cancer. Though the majority of women with UPSC have high risk of recurrence, recurrence limited only to the pleural space has not been previously reported. It is also unusual for it to occur as late as 10 years after the initial treatment as it is usually very aggressive. There is scant information in literature on response to treatment in these patients. A 65-year-old African-American woman was treated for FIGO stage IIA UPSC with total abdominal hysterectomy, bilateral salpingo-oophorectomy, and pelvic lymphadenectomy with P catheter placement, followed by adjuvant external beam radiation. She relapsed 10 years later with right pleural effusion and pleural based nodules. Fluid cytology was consistent with UPSC. She was treated with 6 cycles of carboplatin and paclitaxel with excellent clinical and biochemical response. She continues to remain disease free 5 years later. To our knowledge, this is the first reported case of UPSC recurrence limited to pleura, and this is also the first reported case of UPSC recurrence without evidence of disease 5 years after palliative chemotherapy.
子宫浆液性乳头状癌（UPSC）是子宫内膜癌的一种侵袭性亚型。尽管大多数UPSC患者有较高的复发风险，但此前尚未有仅局限于胸腔的复发报道。它在初始治疗10年后才发生也不常见，因为它通常具有很强的侵袭性。关于这些患者对治疗反应的文献资料很少。一名65岁的非裔美国女性因FIGO IIA期UPSC接受了全腹子宫切除术、双侧输卵管卵巢切除术和盆腔淋巴结清扫术并放置P导管，随后进行辅助外照射放疗。她在10年后复发，出现右侧胸腔积液和胸膜下结节。胸水细胞学检查结果与UPSC相符。她接受了6个周期的卡铂和紫杉醇治疗，临床和生化反应良好。5年后她仍无疾病复发。据我们所知，这是首例报道的UPSC复发局限于胸膜的病例，也是首例报道的在姑息化疗5年后无疾病证据的UPSC复发病例。
