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一例原发性诊断八年后出现的恶性转移性嗜铬细胞瘤病例。

A Case of Malignant Metastatic Pheochromocytoma After Eight Years of Primary Diagnosis.

作者信息

Kapur Sakshi, Iqbal Afsheen N, Levin Miles B

机构信息

Department of Internal Medicine, Overlook Medical Center, Summit, New Jersey 07902, USA.

Division of Medical Oncology, Memorial Sloan-Kettering Cancer Center Basking Ridge, 136 Mountain View Boulevard, Basking Ridge, New Jersey 07920, USA.

出版信息

World J Oncol. 2014 Feb;5(1):33-40. doi: 10.14740/wjon760w. Epub 2014 Mar 11.

Abstract

We report a case of a 66-year-old female who presented to the hospital with abdominal discomfort for 3 months. Work-up revealed a 2.4 cm mass in the right adrenal gland. A laparoscopic resection of the adrenal mass was performed and the histopathology was consistent with a pheochromocytoma. Patient was under active surveillance for 8 years, until she developed local recurrence in the right adrenal bed. A right adrenal bed resection and right nephrectomy were performed. Although the tumor margins were positive, none of the sampled lymph nodes (0/6) were positive for metastasis. Patient refused any adjuvant therapy, and was discharged on surveillance from the hospital. A year later, patient was found to have metastatic disease involving her spine, iliac bones, bilateral hips and right dome of the diaphragm. Patient was offered a metaiodobenzylguanidine scan, and positive subsequent treatment with radioactive iodine was discussed with her. However, she denied any further intervention and was made hospice.

摘要

我们报告一例66岁女性,因腹部不适3个月入院。检查发现右肾上腺有一个2.4厘米的肿块。行腹腔镜肾上腺肿块切除术,组织病理学检查结果符合嗜铬细胞瘤。患者接受了8年的积极监测,直至右肾上腺床出现局部复发。遂行右肾上腺床切除术及右肾切除术。尽管肿瘤边缘呈阳性,但所取淋巴结(0/6)均无转移阳性。患者拒绝任何辅助治疗,出院后继续接受监测。一年后,患者被发现发生转移,累及脊柱、髂骨、双侧臀部和右膈穹窿。为患者进行了间碘苄胍扫描,并与她讨论了后续放射性碘阳性治疗方案。然而,她拒绝进一步干预,进入临终关怀阶段。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dda1/5649825/6b9adcba3f98/wjon-05-033-g001.jpg

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