Guo Bin-Bin, Zhang Yu-Qiao, Wang Sheng-Feng, Ding Jin-Song, Zhou Wen-Hu
Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, Hunan, 410013, China.
West China Second University Hospital, Chengdu, Sichuan, 610041, China.
J Forensic Sci. 2018 Jul;63(4):1221-1228. doi: 10.1111/1556-4029.13696. Epub 2017 Nov 17.
Papaveris pericarpium, a natural source of morphine and codeine, is the principal active component in many antitussive traditional Chinese medicines. We herein report the first PK study of papaveris pericarpium in human plasma and urine following oral administration of single (15, 30, 60 mL) and multiple dose (15 mL) of Qiangli Pipa Syrup (MOR 0.1 mg/mL, COD 0.028 mg/mL) by monitoring morphine and codeine using a HPLC-MS/MS method. Their T and t values are independent of dosages, while the AUC linearly increased with higher dosages, indicating linear PK characteristics. AUC increased obviously after multiple doses, indicating possible risk of accumulative toxicity. Urine studies suggested risks of positive opiate drug tests with a cutoff of 300 ng/mL, which lasted 6-14 h at different doses. These results provide important information for clinical safety, efficacy and rational drug use of Qiangli Pipa Syrup and also guide the related judicial expertise of its administration.
罂粟壳是吗啡和可待因的天然来源，是许多止咳类中药的主要活性成分。我们在此报告首次采用高效液相色谱-串联质谱法监测吗啡和可待因，对口服单剂量（15、30、60 mL）和多剂量（15 mL）强力枇杷糖浆（吗啡0.1 mg/mL，可待因0.028 mg/mL）后人血浆和尿液中罂粟壳的药代动力学研究。它们的T和t值与剂量无关，而AUC随剂量增加呈线性增加，表明具有线性药代动力学特征。多剂量给药后AUC明显增加，表明可能存在累积毒性风险。尿液研究表明，以300 ng/mL为临界值进行阿片类药物检测呈阳性的风险，在不同剂量下持续6-14小时。这些结果为强力枇杷糖浆的临床安全性、有效性和合理用药提供了重要信息，也为其用药相关司法鉴定提供了指导。
