Warren E H, Liberman M C
Department of Neurobiology, Harvard Medical School, Boston, Massachusetts.
Hear Res. 1989 Jan;37(2):105-21. doi: 10.1016/0378-5955(89)90033-6.
The suppression by moderate-level contralateral sound of auditory-nerve-fiber responses to ipsilateral stimuli at the characteristic frequency (CF) was studied in barbiturate-anesthetized cats. The dependence of suppression strength on ipsilateral and contralateral stimulus variables, including level, frequency, bandwidth, and timing relationships, was investigated. The principal findings were: (1) Contralateral-sound suppression is greatest when the ipsilateral stimulus level is within the dynamic range of the unit. (2) When the contralateral stimuli are tones, suppression is greatest when the contralateral tone frequency is at or near CF. (3) Units with CFs above 3-4 kHz are only weakly suppressed by contralateral CF tones but more strongly suppressed by contralateral broad-band noise. (4) Continuous contralateral stimuli are significantly more effective suppressors than are gated stimuli. The characteristics of contralateral-sound suppression are compared with the physiology and anatomy of the uncrossed medial olivocochlear efferents, the subset of efferents which are the primary mediators of the effect.
在巴比妥麻醉的猫中，研究了中等强度对侧声音对听神经纤维在特征频率（CF）处对同侧刺激反应的抑制作用。研究了抑制强度对同侧和对侧刺激变量的依赖性，包括强度、频率、带宽和时间关系。主要发现如下：（1）当同侧刺激强度处于单位动态范围内时，对侧声音抑制作用最大。（2）当对侧刺激为纯音时，对侧纯音频率等于或接近CF时抑制作用最大。（3）CF高于3 - 4kHz的单位仅被对侧CF纯音微弱抑制，但被对侧宽带噪声更强抑制。（4）连续对侧刺激比门控刺激是更有效的抑制器。将对侧声音抑制的特征与未交叉的内侧橄榄耳蜗传出神经（传出神经的一个子集，是该效应的主要介导者）的生理和解剖结构进行了比较。
