Griffiths Heidi, Goyal Manu S, Pineda Jose A
Department of Pediatrics, Washington University School of Medicine, St. Louis, MO, USA.
Department of Neuroradiology, Washington University School of Medicine, St. Louis, MO, USA.
Childs Nerv Syst. 2017 Oct;33(10):1719-1726. doi: 10.1007/s00381-017-3514-y. Epub 2017 Sep 6.
Age-dependent changes in brain metabolism may influence the response to and tolerance of secondary insults, potentially affecting outcomes. More complete characterization of brain metabolism across the clinical trajectory of severe pediatric TBI is needed to improve our ability to measure and better mitigate the impact of secondary insults. Better management of secondary insults will impact clinical care and the probability of success of future neuroprotective clinical trials. Improved bedside monitoring and imaging technologies will be required to achieve these goals. Effective and sustained integration of brain metabolism information into the pediatric critical care setting will be equally challenging and important.
大脑代谢的年龄依赖性变化可能会影响对继发性损伤的反应和耐受性，从而潜在地影响预后。需要更全面地描述重度小儿创伤性脑损伤临床病程中的大脑代谢情况，以提高我们测量和更好地减轻继发性损伤影响的能力。更好地管理继发性损伤将影响临床护理以及未来神经保护临床试验成功的可能性。实现这些目标需要改进床边监测和成像技术。将大脑代谢信息有效且持续地整合到儿科重症监护环境中同样具有挑战性且至关重要。
