脓毒症的生物标志物。

Biomarkers in Sepsis.

机构信息

Division of Laboratory Specialties, Center for Experimental Molecular Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, Room G2-130, Amsterdam 1105AZ, The Netherlands.

Division of Laboratory Specialties, Center for Experimental Molecular Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, Room G2-130, Amsterdam 1105AZ, The Netherlands; Division of Infectious Diseases, Academic Medical Center, University of Amsterdam, Meibergdreef 9, Room G2-130, Amsterdam 1105AZ, The Netherlands.

出版信息

Crit Care Clin. 2018 Jan;34(1):139-152. doi: 10.1016/j.ccc.2017.08.010. Epub 2017 Oct 12.

DOI:10.1016/j.ccc.2017.08.010

PMID:29149935

Abstract

A biomarker is a characteristic by which a (patho)physiologic process can be identified. Biomarkers can be of diagnostic value (to discriminate infection from noninfectious conditions or to determine the causative pathogen), of prognostic value (assigning risk profiles and predict outcome), and in the future may be of theranostic value (aid in selection and monitoring of therapy). Systems biology provides a promising tool for the discovery of novel biomarkers. Biomarkers can be the key to personalized targeted treatment in the future clinical management of sepsis.

摘要

生物标志物是可用于识别（病理）生理过程的特征。生物标志物具有诊断价值（用于区分感染与非传染性疾病，或确定病原体）、预后价值（确定风险概况并预测结果），未来可能还具有治疗价值（辅助选择和监测治疗）。系统生物学为发现新的生物标志物提供了有前途的工具。在未来脓毒症的临床管理中，生物标志物可能是实现个性化靶向治疗的关键。