Department of Trauma Center & Emergency Surgery, The First Affiliated Hospital of Fujian Medical University, 350004 Fuzhou, China.
Department of Trauma Center and Emergency Surgery, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, 350004 Fuzhou, China.
Expert Rev Mol Med. 2024 Apr 11;26:e7. doi: 10.1017/erm.2024.3.
Trauma is a significant health issue that not only leads to immediate death in many cases but also causes severe complications, such as sepsis, thrombosis, haemorrhage, acute respiratory distress syndrome and traumatic brain injury, among trauma patients. Target protein identification technology is a vital technique in the field of biomedical research, enabling the study of biomolecular interactions, drug discovery and disease treatment. It plays a crucial role in identifying key protein targets associated with specific diseases or biological processes, facilitating further research, drug design and the development of treatment strategies. The application of target protein technology in biomarker detection enables the timely identification of newly emerging infections and complications in trauma patients, facilitating expeditious medical interventions and leading to reduced post-trauma mortality rates and improved patient prognoses. This review provides an overview of the current applications of target protein identification technology in trauma-related complications and provides a brief overview of the current target protein identification technology, with the aim of reducing post-trauma mortality, improving diagnostic efficiency and prognostic outcomes for patients.
创伤是一个严重的健康问题,不仅在许多情况下导致立即死亡,还会导致严重的并发症,如脓毒症、血栓形成、出血、急性呼吸窘迫综合征和创伤性脑损伤等。靶蛋白鉴定技术是生物医学研究领域的一项重要技术,可用于研究生物分子相互作用、药物发现和疾病治疗。它在确定与特定疾病或生物过程相关的关键蛋白靶标方面发挥着关键作用,有助于进一步的研究、药物设计和治疗策略的开发。靶蛋白技术在生物标志物检测中的应用可以及时识别创伤患者中新出现的感染和并发症,促进迅速的医疗干预,从而降低创伤后死亡率并改善患者预后。本综述概述了靶蛋白鉴定技术在创伤相关并发症中的应用,并简要概述了当前的靶蛋白鉴定技术,旨在降低创伤后死亡率、提高诊断效率和改善患者预后。