Department of Anatomy, TU Dresden, Dresden, Germany.
282 Harison Ave., Harrison, NY, USA.
Med Hypotheses. 2017 Nov;109:1-5. doi: 10.1016/j.mehy.2017.09.009. Epub 2017 Sep 15.
The pathogenesis of glaucoma is complex which has led to numerous hypothesizes concerning the important factors creating this specific type of inner retinal degeneration namely apoptosis of retinal ganglion cells. We favor a primary vascular etiology and provide evidence that the pathogenesis of glaucoma should not be confined to changes exclusively at the optic nerve head but must include changes occurring in the peripheral retina with particular emphasis on the watershed zones of both the retina and choroid. This focus may help to sharpen ones awareness for early glaucoma treatment particularly in patients with minimal findings suggestive of glaucoma.
青光眼的发病机制较为复杂，提出了许多有关导致这种特定类型的内视网膜变性的重要因素的假说，即视网膜神经节细胞的凋亡。我们倾向于一种主要的血管病因，并提供证据表明，青光眼的发病机制不应仅限于视神经头部的变化，而必须包括在周边视网膜中发生的变化，特别强调视网膜和脉络膜的分水岭区域。这种关注可能有助于提高对早期青光眼治疗的认识，特别是在那些仅有轻微青光眼表现的患者中。
