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婴儿血管瘤:单中心7年经验

Infantile hemangiomas: a 7-year experience of a single-center.

作者信息

Bota Mădălina, Popa Gheorghe, Blag Cristina Lucia, Leucuta Daniel-Corneliu, Tătaru Alexandru

机构信息

Department of Pediatrics, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.

Department of Medical Informatics and Biostatistics, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.

出版信息

Clujul Med. 2017;90(4):396-400. doi: 10.15386/cjmed-781. Epub 2017 Oct 20.

Abstract

OBJECTIVES

The aim of the study was to describe the historical and clinical characteristics of hemangiomas in a series of cases of our clinic.

METHODS

This is a retrospective study of 36 patients with infantile hemangiomas consulted in our clinic.

RESULTS

We had 14 multiple hemangiomas, and 1 kaposiform hemangioendothelioma. Almost two-thirds involved the cephalic extremity, and 76% of the cases were treated. Pregnancy risk factors included prematurity, low-birth weight and respiratory distress syndrome. Propranolol was used in 22 cases, followed by prednisone in 3 cases. Vincristine and interferon were used as associated therapies or as second line therapies. Two hemangiomas had complications, one ulceration and a Kasabach-Merritt syndrome. All the patients had a good evolution.

CONCLUSIONS

Our study results regarding the involvement of pregnancy and birth risk factors in developing infantile hemangiomas is similar to literature data. The majority of patients had at least one risk factor suggesting that at least one trigger to develop an infantile hemangioma is necessary. Our study shows that the cephalic extremity is mostly involved, and because of its potential complications they are most likely to be treated. The study shows that propranolol is the leading treatment option with few and mild side effects.

摘要

目的

本研究旨在描述我院一系列血管瘤病例的病史及临床特征。

方法

这是一项对我院36例婴儿血管瘤患者的回顾性研究。

结果

我们有14例多发性血管瘤和1例卡波西型血管内皮瘤。近三分之二累及头端,76%的病例接受了治疗。妊娠风险因素包括早产、低出生体重和呼吸窘迫综合征。22例使用了普萘洛尔,3例使用了泼尼松。长春新碱和干扰素用作联合治疗或二线治疗。有2例血管瘤出现并发症,1例溃疡和1例卡萨巴赫-梅里特综合征。所有患者病情均好转。

结论

我们关于妊娠和出生风险因素与婴儿血管瘤发生关系的研究结果与文献数据相似。大多数患者至少有一个风险因素,这表明至少有一个触发婴儿血管瘤发生的因素是必要的。我们的研究表明头端最常受累,且因其潜在并发症最有可能接受治疗。研究表明普萘洛尔是主要的治疗选择,副作用少且轻微。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b619/5683828/93669b429a04/cm-90-396f1.jpg

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本文引用的文献

1
Excellent outcome of medical treatment for Kasabach-Merritt syndrome: a single-center experience.
Blood Res. 2016 Dec;51(4):256-260. doi: 10.5045/br.2016.51.4.256. Epub 2016 Dec 23.
2
[Spanish consensus on infantile haemangioma].
An Pediatr (Barc). 2016 Nov;85(5):256-265. doi: 10.1016/j.anpedi.2015.10.004. Epub 2015 Nov 19.
4
Serum-level changes of vascular endothelial growth factor in children with infantile hemangioma after oral propranolol therapy.
Pediatr Dermatol. 2013 Sep-Oct;30(5):549-53. doi: 10.1111/pde.12192. Epub 2013 Aug 5.
5
Propranolol therapy of infantile hemangiomas: efficacy, adverse effects, and recurrence.
Pediatr Surg Int. 2013 Jun;29(6):575-81. doi: 10.1007/s00383-013-3283-y. Epub 2013 Mar 22.
6
[Infantile hemangioma: update and treatment].
Arch Pediatr. 2013 May;20(5):517-22. doi: 10.1016/j.arcped.2013.01.052. Epub 2013 Mar 6.
7
Update on infantile hemangiomas.
Semin Perinatol. 2013 Feb;37(1):49-58. doi: 10.1053/j.semperi.2012.11.003.
8
Propranolol and infantile hemangiomas four years later: a systematic review.
Pediatr Dermatol. 2013 Mar-Apr;30(2):182-91. doi: 10.1111/pde.12089. Epub 2013 Feb 14.
9
Maternal and perinatal risk factors for infantile hemangioma: a case-control study.
Pediatr Dermatol. 2013 Jul-Aug;30(4):457-61. doi: 10.1111/pde.12042. Epub 2012 Dec 26.
10
Effects of propranolol on the proliferation and apoptosis of hemangioma-derived endothelial cells.
J Pediatr Surg. 2012 Dec;47(12):2216-23. doi: 10.1016/j.jpedsurg.2012.09.008.

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