一些新型3-苄基-4,8-二甲基苯并吡喃酮衍生物的合成与抗癌活性评价
Synthesis and Anticancer Evaluation of Some New 3-Benzyl-4,8-Dimethylbenzopyrone Derivatives.
作者信息
El-Ansary Sohair L, Abdel Rahman Doaa E, Abdel Ghany Lina M A
机构信息
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, Cairo 11562, Egypt.
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Misr University for Science and Technology, Misr, Egypt.
出版信息
Open Med Chem J. 2017 Sep 21;11:81-91. doi: 10.2174/1874104501711010081. eCollection 2017.
INTRODUCTION
New benzopyrone derivatives such as Schiff's like compounds, acetohydrazides or substituted with oxadiazole or pyrazole heterocycles were synthesized from parent acid hydrazide compound .
METHODS AND MATERIALS
Structures of the synthesized compounds were elucidated using IR, NMR and mass spectroscopy. All the synthesized derivatives were selected by National Cancer Institute (NCI), Bethesda, and evaluated for their anticancer activity in the full NCI 60 cell lines panel assay.
RESULTS AND CONCLUSION
Schiffs like compounds and were found to have good growth inhibition % against numerous cell lines that belong mainly to leukemia, non-small cell lung, CNS and breast Cancer subpanels.
引言
新型苯并吡喃衍生物，如席夫碱类化合物、乙酰肼或被恶二唑或吡唑杂环取代的化合物，是由母体酰肼化合物合成的。
方法与材料
使用红外光谱、核磁共振光谱和质谱对合成化合物的结构进行了阐明。所有合成衍生物均由美国国立癌症研究所（NCI），贝塞斯达挑选，并在完整的NCI 60细胞系面板测定中评估其抗癌活性。
结果与结论
发现席夫碱类化合物 和 对许多主要属于白血病、非小细胞肺癌、中枢神经系统和乳腺癌亚组的细胞系具有良好的生长抑制率。
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