Tekgündüz Emre, Arat Mutlu, Göker Hakan, Özdoğu Hakan, Kaynar Leylagül, Çağırgan Seçkin, Erkurt Mehmet Ali, Vural Filiz, Kiki İlhami, Altuntaş Fevzi, Demirkan Fatih
Ankara Oncology Hospital, Hematology and HCT Clinic, Ankara, Turkey.
Sisli Florence Nightingale Hospital, HSCT Unit, İstanbul, Turkey.
Transfus Apher Sci. 2017 Dec;56(6):845-849. doi: 10.1016/j.transci.2017.11.025. Epub 2017 Nov 10.
Autologous hematopoietic cell transplantation (AHCT) is a routinely used procedure in the treatment of adult patients presenting with multiple myeloma (MM), Hodgkin lymphoma (HL) and various subtypes of non-Hodgkin lymphoma (NHL) in upfront and relapsed/refractory settings. Successful hematopoietic progenitor cell mobilization (HPCM) and collection are the rate limiting first steps for application of AHCT. In 2015, almost 1700 AHCT procedures have been performed for MM, HL and NHL in Turkey. Although there are recently published consensus guidelines addressing critical issues regarding autologous HPCM, there is a tremendous heterogeneity in terms of mobilization strategies of transplant centers across the world. In order to pave the way to a more standardized HPCM approach in Turkey, Turkish Society of Apheresis (TSA) assembled a working group consisting of experts in the field. Here we report the position statement of TSA regarding autologous HPCM mobilization strategies in adult patients presenting with MM and lymphoma.
自体造血细胞移植(AHCT)是治疗成年多发性骨髓瘤(MM)、霍奇金淋巴瘤(HL)以及各种非霍奇金淋巴瘤(NHL)亚型初治和复发/难治性患者的常规治疗手段。成功的造血祖细胞动员(HPCM)和采集是AHCT应用的限速首要步骤。2015年,土耳其针对MM、HL和NHL实施了近1700例AHCT手术。尽管近期已发布了关于自体HPCM关键问题的共识指南,但全球各移植中心的动员策略仍存在极大差异。为在土耳其推行更标准化的HPCM方法,土耳其单采学会(TSA)组建了一个由该领域专家组成的工作组。在此,我们报告TSA关于成年MM和淋巴瘤患者自体HPCM动员策略的立场声明。