多发性硬化症患者血清CCL20及其与SIRT1活性的关联。
Serum CCL20 and its association with SIRT1 activity in multiple sclerosis patients.
作者信息
Li Rui, Sun Xiaobo, Shu Yaqing, Wang Yuge, Xiao Li, Wang Zhanhang, Hu Xueqiang, Kermode Allan G, Qiu Wei
机构信息
Multiple Sclerosis Center, Department of Neurology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong Province, China.
Department of Neurology, Guangdong 999 Brain Hospital, China.
出版信息
J Neuroimmunol. 2017 Dec 15;313:56-60. doi: 10.1016/j.jneuroim.2017.10.013. Epub 2017 Oct 19.
CCL20 is a potentially important component in the pathogenesis of multiple sclerosis (MS). SIRT1 exhibits a negative regulatory effect on a variety of inflammatory cytokines and can relieve experimental autoimmune encephalomyelitis. The association between the level of CCL20 and SIRT1 activity in MS patients has not been investigated. In the present study, blood samples were collected from 38 RRMS patients and 40 healthy controls. The serum CCL20 levels were measured by ELISA. SIRT1 activity was evaluated by fluorometric assay. We revealed elevated serum CCL20 concentrations in MS, and discovered an inverse correlation between CCL20 and SIRT1 activity in MS patients.
CCL20是多发性硬化症（MS）发病机制中一个潜在的重要组成部分。SIRT1对多种炎性细胞因子具有负调控作用，并可缓解实验性自身免疫性脑脊髓炎。尚未对MS患者中CCL20水平与SIRT1活性之间的关联进行研究。在本研究中，采集了38例复发缓解型多发性硬化症（RRMS）患者和40名健康对照者的血样。采用酶联免疫吸附测定法（ELISA）检测血清CCL20水平。通过荧光测定法评估SIRT1活性。我们发现MS患者血清CCL20浓度升高，并发现MS患者中CCL20与SIRT1活性呈负相关。
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