Department of Neurology, Clinical Hospital "Sveti Duh", Sveti Duh 64, 10 000 Zagreb, Croatia.
Neurology Clinic, Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Josipa Huttlera 4, 31 000 Osijek, Croatia.
Int J Mol Sci. 2024 Jul 24;25(15):8064. doi: 10.3390/ijms25158064.
Epstein-Barr virus (EBV) infection and various chemokines, including CCL20, CXCL8 and CXCL10 are considered to participate in the pathogenesis of multiple sclerosis (MS), and several studies point to a direct regulatory effect of EBV on the expression of these chemokines. In our study we hypothesized that serum concentrations of CCL20, CXCL8 and CXCL0 are induced in patients with relapsing-remitting MS (RRMS) in comparison to healthy individuals, and that they are associated with EBV infection. Serum concentrations of CXCL8 and CXCL10 were lower in RRMS patients in relapse in comparison to healthy controls. Although potential effects of corticosteroid therapy introduced in a subgroup of RRMS patients prior to sampling were excluded by subgroup comparison, this possibility has to be considered while interpreting the results. We found an inverse association between serum concentrations of CXCL8 and anti-Epstein-Barr Virus Nuclear Antigen (EBNA) IgG and decreased expression of CXCL8 in peripheral blood mononuclear cells (PBMC) in relapse compared to remission. Lower serum concentrations of CXCL8 and CXCL10 in RRMS patients and decreased peripheral production of CXCL8 in relapse may indicate compensatory anti-inflammatory counter-regulation in MS.
爱泼斯坦-巴尔病毒（EBV）感染和各种趋化因子，包括 CCL20、CXCL8 和 CXCL10，被认为参与了多发性硬化症（MS）的发病机制，有几项研究指出 EBV 对这些趋化因子的表达有直接的调节作用。在我们的研究中，我们假设复发缓解型多发性硬化症（RRMS）患者的血清 CCL20、CXCL8 和 CXCL0 浓度与健康个体相比会升高，并且与 EBV 感染有关。与健康对照组相比，RRMS 患者复发时血清 CXCL8 和 CXCL10 浓度较低。虽然通过亚组比较排除了在取样前接受皮质类固醇治疗的 RRMS 患者亚组中的潜在影响，但在解释结果时需要考虑到这种可能性。我们发现，与缓解期相比，复发期 RRMS 患者的血清 CXCL8 浓度与抗 EBV 核抗原（EBNA）IgG 呈负相关，外周血单个核细胞（PBMC）中 CXCL8 的表达降低。RRMS 患者的血清 CXCL8 和 CXCL10 浓度较低，以及复发时外周 CXCL8 产生减少，可能表明 MS 中存在代偿性抗炎的反调节作用。
