Komatsu Masanori, Nishino Kagetomo, Fujimori Yuki, Haga Yasutoshi, Iwama Nagako, Arakawa Aisaku, Aihara Yoshito, Takeda Hisato, Takahashi Hideaki
Institute of Livestock and Grassland Science, National Agriculture and Food, Research Organization (NARO), Tsukuba, Ibaraki, Japan.
Komatsu Laboratory of Computational Biology for Domestic Animals, Ryugasaki, Ibaraki, Japan.
Anim Sci J. 2018 Feb;89(2):273-288. doi: 10.1111/asj.12947. Epub 2017 Nov 20.
Growth hormone secretagogue receptor 1a (GHSR1a), growth hormone (GH), growth hormone receptor (GHR), non-SMC condensin I complex, subunit G (NCAPG) and stearoyl-CoA desaturase (SCD), are known to play important roles in growth and lipid metabolisms. Single and epistatic effects of the five genes on carcass, price-related and fatty acid (FA) composition traits were analyzed in a commercial Japanese Black cattle population of Ibaraki Prefecture. A total of 650 steers and 116 heifers for carcass and price-related traits, and 158 steers for FA composition traits were used in this study. Epistatic effects between pairs of the five genes were found in several traits. Alleles showing strain-specific differences in the five genes had significant single and epistatic effects in some traits. The data suggest that a TG-repeat polymorphism of the GHSR1a.5'UTR-(TG) locus plays a central role in gene-gene epistatic interaction of FA composition traits in the adipose tissue of Japanese Black cattle.
生长激素促分泌素受体1a（GHSR1a）、生长激素（GH）、生长激素受体（GHR）、非SMC凝聚素I复合体亚基G（NCAPG）和硬脂酰辅酶A去饱和酶（SCD），已知在生长和脂质代谢中发挥重要作用。在茨城县的一个日本黑牛商业群体中，分析了这五个基因对胴体、价格相关和脂肪酸（FA）组成性状的单一和上位效应。本研究共使用了650头用于胴体和价格相关性状的阉牛和116头小母牛，以及158头用于FA组成性状的阉牛。在几个性状中发现了这五个基因对之间的上位效应。在这五个基因中表现出品种特异性差异的等位基因在某些性状中具有显著的单一和上位效应。数据表明，GHSR1a.5'UTR-(TG)位点的TG重复多态性在日本黑牛脂肪组织中FA组成性状的基因-基因上位相互作用中起核心作用。
