Liu Yiyan
Nuclear Medicine Service, Department of Radiology, New Jersey Medical School, Rutgers University, University Hospital, 150 Bergen Street, H141, Newark, NJ 07103, USA.
PET Clin. 2018 Jan;13(1):11-18. doi: 10.1016/j.cpet.2017.08.002. Epub 2017 Oct 20.
Some malignant lung neoplasms may demonstrate low or absent uptake on F18-fluorodeoxyglucose (FDG) PET/computed tomography. Pathologic type and clinical stage are independent factors associated with FDG avidity. Among lung malignancies with low FDG avidity, adenocarcinoma in situ and carcinoid are the most common. Early stage disease often has low FDG uptake. Small lesion size is another significant factor associated with negative FDG PET findings, which is due to a partial volume effect. Morphology of lung lesions on anatomic images may also affect FDG avidity. Subsolid pulmonary nodules, ground-glass nodules, or ground-glass opacity may be sources of false-negative PET.
一些恶性肺肿瘤在F18氟脱氧葡萄糖（FDG）PET/计算机断层扫描上可能表现为摄取低或无摄取。病理类型和临床分期是与FDG亲和力相关的独立因素。在FDG亲和力低的肺恶性肿瘤中，原位腺癌和类癌最为常见。早期疾病通常FDG摄取低。病变尺寸小是与FDG PET阴性结果相关的另一个重要因素，这是由于部分容积效应。解剖图像上肺病变的形态也可能影响FDG亲和力。亚实性肺结节、磨玻璃结节或磨玻璃影可能是PET假阴性的来源。
