中枢神经系统脱髓鞘的异常特征：放射学孤立综合征。
Anomalies Characteristic of Central Nervous System Demyelination: Radiologically Isolated Syndrome.
作者信息
Lebrun Christine, Kantarci Orhun H, Siva Aksel, Pelletier Daniel, Okuda Darin T
机构信息
Service de Neurologie, Centre de Ressources et de Compétences Sclérose en Plaques, Université Nice Sophia Antipolis, Hôpital Pasteur 2, 30 voie romaine, Nice Cedex 06002, France.
Department of Neurology, Mayo Clinic College of Medicine, 200 1st Street SW, Rochester, MN 55902, USA.
出版信息
Neurol Clin. 2018 Feb;36(1):59-68. doi: 10.1016/j.ncl.2017.08.004.
Radiologically isolated syndrome (RIS) was defined in 2009 for asymptomatic patients who presented incidentally identified white matter anomalies within the central nervous system suggestive of multiple sclerosis (MS). Approximately one-third of RIS subjects will have a seminal clinical demyelinating event within 5 years of the identification of their abnormal MRI. Clinical evolution mirrors relapsing remitting or progressive forms of MS. Pejorative factors for clinical conversion are male gender, age younger than 35 years, and spinal cord lesions.
放射学孤立综合征（RIS）于2009年被定义，指的是中枢神经系统偶然发现有提示多发性硬化（MS）的白质异常但无症状的患者。大约三分之一的RIS患者在其MRI异常被发现后的5年内会发生首次临床脱髓鞘事件。临床病程反映复发缓解型或进展型MS。临床转化的不良因素包括男性、年龄小于35岁以及脊髓病变。
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