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脊髓压迫症患者的非药物干预措施:系统评价。

Non-pharmacological interventions in patients with spinal cord compression: a systematic review.

机构信息

Department of Nursing, University of Valencia, c/Jaume Roig s/n, 46010, Valencia, Spain.

出版信息

J Neurooncol. 2018 Feb;136(3):423-434. doi: 10.1007/s11060-017-2684-5. Epub 2017 Nov 20.

DOI:10.1007/s11060-017-2684-5
PMID:29159776
Abstract

Spinal cord compression is a complex and challenging condition that greatly affects the quality of life. Non-pharmacological techniques have only been studied to a very lesser extent; although they are evidence to be beneficial. We performed Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) analysis of the scientific literature in several databases (Medline, Cochrane, Scopus, Cuiden, Pubmed, Lilacs and Embase); using the following keywords: spinal cord compression, spine compression, mobilization, positioning, brace and bracing. Eleven studies met the inclusion criteria and were finally included in the systematic review. 3 of them were related to metastatic spinal cord compression, 5 to spinal cord compression due to other causes and the last 3 of them regarded the health professional´s knowledge in oncology patients. In all cases, it seems possible to manage spinal cord compression by using external mobilization and braces and that this treatment is beneficial to patients. Positioning plays a massive role in the disease and can improve or worsen the condition when used improperly; the supine position is overused and can have a negative impact both physically and psychologically. Non-pharmacological interventions could be useful for pain management, cardiovascular alterations and patients' well-being. One randomized clinical trial demonstrated that massage therapy, using either broad compression massage or light contact touch massage improved pain control. There is an urgent need of randomized clinical trials with these interventions in order to achieve an improved care of these patients.

摘要

脊髓压迫是一种复杂且具有挑战性的病症,极大地影响了生活质量。非药物治疗技术仅在非常有限的程度上进行了研究;尽管它们被证明是有益的。我们在多个数据库(Medline、Cochrane、Scopus、Cuiden、Pubmed、Lilacs 和 Embase)中对科学文献进行了系统评价和荟萃分析(PRISMA)分析;使用以下关键词:脊髓压迫、脊柱压迫、活动、定位、支架和支具。11 项研究符合纳入标准,最终被纳入系统评价。其中 3 项与转移性脊髓压迫有关,5 项与其他原因引起的脊髓压迫有关,最后 3 项与肿瘤患者健康专业人员的知识有关。在所有情况下,似乎可以通过使用外部活动和支架来治疗脊髓压迫,并且这种治疗对患者有益。定位在疾病中起着重要作用,如果使用不当,可能会改善或恶化病情;仰卧位被过度使用,可能会对身体和心理产生负面影响。非药物干预措施可能对疼痛管理、心血管改变和患者的幸福感有用。一项随机临床试验表明,按摩疗法,无论是使用广泛的压缩按摩还是轻度接触触摸按摩,都可以改善疼痛控制。迫切需要对这些干预措施进行随机临床试验,以改善对这些患者的护理。

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本文引用的文献

1
Acute Spinal Cord Compression.急性脊髓压迫症
N Engl J Med. 2017 Apr 6;376(14):1358-1369. doi: 10.1056/NEJMra1516539.
2
Management of neuro-oncologic emergencies.神经肿瘤急症的管理
Handb Clin Neurol. 2017;141:715-741. doi: 10.1016/B978-0-444-63599-0.00039-9.
3
Malignant Spinal Cord Compression: Adapting Conventional Rehabilitation Approaches.恶性脊髓压迫症:调整传统康复方法
Phys Med Rehabil Clin N Am. 2017 Feb;28(1):101-114. doi: 10.1016/j.pmr.2016.08.007.
4
Continuous Cervical Epidural Analgesia in Metastatic Spinal Cord Compression.转移性脊髓压迫症中的连续颈段硬膜外镇痛
Indian J Palliat Care. 2016 Oct-Dec;22(4):507-510. doi: 10.4103/0973-1075.191860.
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Decompression surgery for spinal metastases: a systematic review.脊柱转移瘤减压手术:一项系统综述
Neurosurg Focus. 2016 Aug;41(2):E2. doi: 10.3171/2016.6.FOCUS16166.
6
Spinal disease in myeloma: cohort analysis at a specialist spinal surgery centre indicates benefit of early surgical augmentation or bracing.骨髓瘤中的脊柱疾病:在一家专业脊柱外科中心进行的队列分析表明早期手术强化或支具治疗有益。
BMC Cancer. 2016 Jul 11;16:444. doi: 10.1186/s12885-016-2495-7.
7
Multiple myeloma presenting with acute bony spinal cord compression and mechanical instability successfully managed nonoperatively.多发性骨髓瘤伴急性骨性脊髓压迫和机械性不稳定,非手术治疗成功。
Spine J. 2016 Aug;16(8):e567-70. doi: 10.1016/j.spinee.2016.03.011. Epub 2016 Mar 17.
8
Extrinsic thoracic spinal cord compression related to supine position: from diagnosis to the creation of a spinal protection shield.与仰卧位相关的胸段脊髓外源性压迫:从诊断到脊髓保护罩的创建
Spine J. 2016 Jan 1;16(1):117-22. doi: 10.1016/j.spinee.2015.09.041. Epub 2015 Sep 28.
9
Positioning and spinal bracing for pain relief in metastatic spinal cord compression in adults.成人转移性脊髓压迫症疼痛缓解的体位与脊柱支具治疗
Cochrane Database Syst Rev. 2015 Sep 24;2015(9):CD007609. doi: 10.1002/14651858.CD007609.pub3.
10
Interventions for the treatment of metastatic extradural spinal cord compression in adults.成人转移性硬膜外脊髓压迫症的治疗干预措施。
Cochrane Database Syst Rev. 2015 Sep 4;2015(9):CD006716. doi: 10.1002/14651858.CD006716.pub3.