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下尿路梗阻的胎儿手术:干预前分期的重要性。

Fetal surgery for lower urinary tract obstruction: the importance of staging prior to intervention.

作者信息

Enninga Elizabeth A, Ruano Rodrigo

机构信息

Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Mayo Clinic College of Medicine, Rochester, MN, USA.

Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Mayo Clinic College of Medicine, Rochester, MN, USA -

出版信息

Minerva Pediatr. 2018 Jun;70(3):263-269. doi: 10.23736/S0026-4946.17.05105-2. Epub 2017 Nov 21.

DOI:10.23736/S0026-4946.17.05105-2
PMID:29160637
Abstract

Fetal lower urinary tract obstruction (LUTO) is a heterogeneous pathology associated with a high morbidity and mortality due to pulmonary hypoplasia. Previously, when a fetus was diagnosed on ultrasound with LUTO, expectant care or termination was the only option; this has changed because of fetal surgical intervention. Vesicoamniotic shunts and cystoscopy are the current methods utilized to treat LUTO; however, it remains difficult to determine whether fetal prognosis favors intervention and long-term outcome follow-up has been limited. This review covers the history and current challenges of fetal intervention for obstructive uropathies. We also present the Ruano's LUTO staging system which integrates information from fetal urine analysis with ultrasound findings to assess whether a specific fetal intervention is recommended. Utilizing a standard staging system that is readily adopted by providers carrying out fetal surgery is crucial for determining the true impact on outcomes intervention has on fetuses diagnosed with LUTO.

摘要

胎儿下尿路梗阻(LUTO)是一种异质性病理状况,因肺发育不全而具有较高的发病率和死亡率。以前,当胎儿在超声检查中被诊断为LUTO时,期待治疗或终止妊娠是唯一的选择;由于胎儿手术干预,这种情况已经发生了变化。羊膜腔分流术和膀胱镜检查是目前用于治疗LUTO的方法;然而,仍然难以确定胎儿预后是否有利于干预,并且长期结果随访一直有限。本综述涵盖了胎儿干预治疗梗阻性尿路疾病的历史和当前挑战。我们还介绍了鲁阿诺的LUTO分期系统,该系统将胎儿尿液分析信息与超声检查结果相结合,以评估是否建议进行特定的胎儿干预。对于实施胎儿手术的医疗人员来说,采用一个易于采用的标准分期系统对于确定干预对被诊断为LUTO的胎儿的结局的真正影响至关重要。

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Fetal surgery for lower urinary tract obstruction: the importance of staging prior to intervention.下尿路梗阻的胎儿手术:干预前分期的重要性。
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引用本文的文献

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Indications and Outcomes of Fetal Cystoscopy for Lower Urinary Tract Obstruction: A Comprehensive Review.胎儿膀胱镜检查治疗下尿路梗阻的适应证与结局:一项综述
Prenat Diagn. 2025 Jan;45(1):89-101. doi: 10.1002/pd.6721. Epub 2024 Dec 18.
2
Advancing the state of the art in congenital obstructive uropathy.推动先天性梗阻性尿路病的技术发展水平。
Nat Rev Urol. 2025 May;22(5):249-250. doi: 10.1038/s41585-024-00976-7.
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Minimally Invasive Bimanual Fetal Surgery-A Review.微创双手法胎儿手术——综述
Children (Basel). 2022 Sep 13;9(9):1377. doi: 10.3390/children9091377.
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Serial Amnioinfusion as Regenerative Therapy for Pulmonary Hypoplasia in Fetuses With Intrauterine Renal Failure or Severe Renal Anomalies: Systematic Review and Future Perspectives.连续羊膜腔灌注作为宫内肾衰竭或严重肾异常胎儿肺发育不全的再生治疗:系统评价与未来展望
Mayo Clin Proc Innov Qual Outcomes. 2020 Aug 5;4(4):391-409. doi: 10.1016/j.mayocpiqo.2020.04.008. eCollection 2020 Aug.