Enninga Elizabeth A, Ruano Rodrigo
Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Mayo Clinic College of Medicine, Rochester, MN, USA.
Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Mayo Clinic College of Medicine, Rochester, MN, USA -
Minerva Pediatr. 2018 Jun;70(3):263-269. doi: 10.23736/S0026-4946.17.05105-2. Epub 2017 Nov 21.
Fetal lower urinary tract obstruction (LUTO) is a heterogeneous pathology associated with a high morbidity and mortality due to pulmonary hypoplasia. Previously, when a fetus was diagnosed on ultrasound with LUTO, expectant care or termination was the only option; this has changed because of fetal surgical intervention. Vesicoamniotic shunts and cystoscopy are the current methods utilized to treat LUTO; however, it remains difficult to determine whether fetal prognosis favors intervention and long-term outcome follow-up has been limited. This review covers the history and current challenges of fetal intervention for obstructive uropathies. We also present the Ruano's LUTO staging system which integrates information from fetal urine analysis with ultrasound findings to assess whether a specific fetal intervention is recommended. Utilizing a standard staging system that is readily adopted by providers carrying out fetal surgery is crucial for determining the true impact on outcomes intervention has on fetuses diagnosed with LUTO.
胎儿下尿路梗阻(LUTO)是一种异质性病理状况,因肺发育不全而具有较高的发病率和死亡率。以前,当胎儿在超声检查中被诊断为LUTO时,期待治疗或终止妊娠是唯一的选择;由于胎儿手术干预,这种情况已经发生了变化。羊膜腔分流术和膀胱镜检查是目前用于治疗LUTO的方法;然而,仍然难以确定胎儿预后是否有利于干预,并且长期结果随访一直有限。本综述涵盖了胎儿干预治疗梗阻性尿路疾病的历史和当前挑战。我们还介绍了鲁阿诺的LUTO分期系统,该系统将胎儿尿液分析信息与超声检查结果相结合,以评估是否建议进行特定的胎儿干预。对于实施胎儿手术的医疗人员来说,采用一个易于采用的标准分期系统对于确定干预对被诊断为LUTO的胎儿的结局的真正影响至关重要。