Flentje M, Weischedel U, Wieland C
Radiologische Klinik, Universität Heidelberg, Abteilung Allgemeine Radiologie mit Poliklinik.
Strahlenther Onkol. 1989 Jan;165(1):11-7.
During the period from 1968 through 1984, 197 patients with advanced carcinomas of the oral cavity have been irradiated. The authors investigate the influence of a standardized chemotherapy as initial therapy measure on the subsequent radiotherapy and the therapy results. Whereas 4.2% of patients were submitted to this treatment between 1968 and 1975, 64.5% of patients received a chemotherapy during 1976 and 1984. The remission rate following to cytostatic therapy was 71%; most of them were partial remissions. The influence of chemotherapy manifested itself by an increase of macroscopically radical tumor resections, especially in stage IV, but also by an increased number of radiotherapy interruptions in case of strong mucosal reactions. An increase of the median survival time from 20 to 30.5 months was connected with the intensified therapy. Further on, this difference vanished, and the five-year survival rates were identical.
在1968年至1984年期间，对197例晚期口腔癌患者进行了放射治疗。作者研究了标准化化疗作为初始治疗措施对后续放疗及治疗结果的影响。1968年至1975年间，4.2%的患者接受了这种治疗，而1976年至1984年间，64.5%的患者接受了化疗。细胞抑制治疗后的缓解率为71%；其中大多数为部分缓解。化疗的影响表现为宏观上根治性肿瘤切除率增加，尤其是在IV期，同时在黏膜反应强烈的情况下放疗中断次数也增加。强化治疗使中位生存时间从20个月增加到30.5个月。此外，这种差异消失了，五年生存率相同。
