Department of Chemical Engineering, The Pennsylvania State University, University Park, PA, USA.
Blood Purif. 2018;45(1-3):46-52. doi: 10.1159/000480491. Epub 2017 Nov 22.
The objective of this study was to compare the transport characteristics of highly asymmetric cellulose triacetate (ATA™) membranes with that of both symmetric cellulose triacetate and asymmetric polysulfone membranes.
Data were obtained for solute clearance and sieving coefficients of vitamin B12 and a range of polydisperse dextrans using ATA™ SOLACEA-25H and Optiflux F250NR polysulfone dialyzers. Results for these, and the CT190 symmetric cellulose triacetate dialyzer, were analyzed using available membrane transport models.
The ATA™ had the largest solute clearance, although the homogeneous CT190 dialyzer had the highest sieving coefficients. These differences were a direct result of the differences in the underlying membrane morphology, with the asymmetric ATA™ membrane providing much higher diffusive transport rates (and thus higher solute clearance).
These results demonstrate the importance of membrane morphology on dialyzer transport and provide important insights into the effective clinical performance observed with the highly asymmetric ATA™ dialyzers.
本研究旨在比较高度不对称纤维素三醋酸酯（ATA™）膜与对称纤维素三醋酸酯和不对称聚砜膜的传输特性。
使用 ATA™SOLACEA-25H 和 Optiflux F250NR 聚砜透析器，获得维生素 B12 和一系列多分散葡聚糖的溶质清除率和筛分系数数据。使用现有的膜传输模型分析这些数据以及 CT190 对称纤维素三醋酸酯透析器的数据。
ATA™的溶质清除率最大，尽管均质 CT190 透析器的筛分系数最高。这些差异是由于基础膜形态的差异所致，不对称 ATA™膜提供了更高的扩散传输速率（从而具有更高的溶质清除率）。
这些结果表明膜形态对透析器传输的重要性，并为高度不对称 ATA™透析器观察到的有效临床性能提供了重要的见解。
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