Hou Yixuan, Mi Kun, Sun Lei, Zhou Kaixiang, Wang Lei, Zhang Lan, Liu Zhenli, Huang Lingli
National Reference Laboratory of Veterinary Drug Residues, Huazhong Agricultural University, Wuhan 430070, China.
MAO Key Laboratory for Detection of Veterinary Drug Residues, Huazhong Agricultural University, Wuhan 430070, China.
Pharmaceutics. 2022 Jul 18;14(7):1485. doi: 10.3390/pharmaceutics14071485.
The hollow fiber cartridge has the advantages of good semi-permeability, high surface area to volume ratio, convenient operation, and so on. Its application in chemical analysis, drug in vitro experiment, hemodialysis, and other fields has been deeply studied. This paper introduces the basic structure of hollow fiber cartridge, compares the advantages and disadvantages of a hollow fiber infection model constructed by a hollow fiber cartridge with traditional static model and animal infection model and introduces its application in drug effects, mechanism of drug resistance, and evaluation of combined drug regimen. The principle and application of hollow fiber bioreactors for cell culture and hollow fiber dialyzer for dialysis and filtration were discussed. The hollow fiber cartridge, whether used in drug experiments, artificial liver, artificial kidney, etc., has achieved controllable experimental operation and efficient and accurate experimental results, and will provide more convenience and support for drug development and clinical research in the future.
中空纤维柱具有半透性良好、表面积与体积比高、操作方便等优点。其在化学分析、药物体外实验、血液透析等领域的应用已得到深入研究。本文介绍了中空纤维柱的基本结构，比较了用中空纤维柱构建的中空纤维感染模型与传统静态模型及动物感染模型的优缺点，并介绍了其在药物作用、耐药机制及联合用药方案评价中的应用。讨论了用于细胞培养的中空纤维生物反应器和用于透析与过滤的中空纤维透析器的原理及应用。中空纤维柱无论是用于药物实验、人工肝、人工肾等，都实现了可控的实验操作以及高效准确的实验结果，未来将为药物研发和临床研究提供更多便利与支持。
