生物磷灰石中潜在金属阳离子交换的体外模型

In vitro model of potential metal cation exchanges in biological apatite.

作者信息

Shi Haishan, Zhang Jing, Ye Xiaoling, Wu Tingting, Ye Jiandong

机构信息

National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, 382 Zhonghuan Road East, Panyu District, Guangzhou 510006, People's Republic of China; School of Materials Science and Engineering, South China University of Technology, 381 Wushan Road, Tianhe District, Guangzhou 510640, People's Republic of China; and College of Chemistry and Materials Science, Jinan University, 601 West Huangpu Avenue, Tianhe District, Guangzhou 510632, People's Republic of China.

Tissue Engineering and Biophotonics Research Division, King's College London Dental Institute, King's Health Partners, London SE1 9RT, United Kingdom.

出版信息

Biointerphases. 2017 Nov 21;13(1):018501. doi: 10.1116/1.5004453.

DOI:10.1116/1.5004453

PMID:29161878

Abstract

Biological apatite is ion-doped and provides an active pool for the exchange with foreign impurity ions. In this work, an in vitro model of hydrated metastable octacalcium phosphate (OCP) crystals was established to mimetically investigate the distinct exchange of trivalent and divalent cations (Fe and Sr) with biological apatite. Fe significantly promoted the collapses of OCP crystals and the formation of amorphous sol-like ferric phosphates, while Sr facilitated the epitaxial growth and stability of OCP crystals. The involvement of Ca maintained the crystalline integrity and inhibited the ion exchange within OCP crystals. This in vitro model would lay the foundation for the further investigation of the metabolism of biological apatite.

摘要

生物磷灰石含有离子掺杂，为与外来杂质离子的交换提供了一个活性库。在本研究中，建立了水合亚稳八钙磷酸盐（OCP）晶体的体外模型，以模拟研究三价和二价阳离子（铁和锶）与生物磷灰石的不同交换情况。铁显著促进了OCP晶体的崩塌和无定形溶胶状磷酸铁的形成，而锶则促进了OCP晶体的外延生长和稳定性。钙的参与维持了晶体的完整性，并抑制了OCP晶体内的离子交换。这个体外模型将为进一步研究生物磷灰石的代谢奠定基础。