Kung I T, Yuen R W
Institute of Pathology, Queen Elizabeth Hospital, Kowloon, Hong Kong.
Acta Cytol. 1989 Jan-Feb;33(1):53-60.
Although fine needle aspiration (FNA) of the thyroid has been found to be useful in selecting patients for surgery in most cases, the cytologic differentiation of cellular colloid nodules from follicular neoplasms has not been possible because of the scanty amount of tissue obtained by this technique and because of the infrequent preparation of cell blocks, thus precluding appreciation of the tissue architecture. Review of the histology of nodular goiters and follicular neoplasms and comparison of their morphology in smears and cell blocks from FNA specimens with the histology of the surgically excised specimens in 74 cases revealed the presence of hyperplastic papillae and fragments of dilated follicles in the aspirates of most cases of colloid nodules. These two features appear to be specific for colloid nodules and are useful for distinguishing colloid nodules from follicular neoplasms. The merits of using a 21-gauge needle and of preparing cell blocks in thyroid studies are also discussed.
尽管甲状腺细针穿刺抽吸活检（FNA）已被证明在大多数情况下有助于筛选需要手术的患者，但由于该技术获取的组织量少且很少制备细胞块，无法对细胞性胶样结节与滤泡性肿瘤进行细胞学鉴别，从而无法评估组织结构。回顾74例结节性甲状腺肿和滤泡性肿瘤的组织学，并将FNA标本涂片和细胞块中的形态与手术切除标本的组织学进行比较，发现大多数胶样结节病例的抽吸物中存在增生性乳头和扩张滤泡的碎片。这两个特征似乎是胶样结节所特有的，有助于将胶样结节与滤泡性肿瘤区分开来。本文还讨论了在甲状腺研究中使用21号针和制备细胞块的优点。
