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韩国与[疾病名称]相关疾病患者分离菌株的特征分析。 （注：原文中“-associated Disease”部分信息缺失，这里补充了“[疾病名称]”以便完整理解句子意思）

Characterization of Strains Isolated from Patients with -associated Disease in Korea.

作者信息

Cho Seung-Hak, Chon Jung-Whan, Seo Kun-Ho, Kim Young Kwon, Kim Jung-Beom, Bak Young-Seok, Jung Woon-Won, Kim Cheorl-Ho, Choi Jong Tae

机构信息

Division of Bacterial Disease Research, Center for Infectious Disease Research, Korea National Institute of Health, Cheongju, Korea.

KU Center for Food Safety, College of Veterinary Medicine, Konkuk University, Seoul, Korea.

出版信息

Osong Public Health Res Perspect. 2017 Oct;8(5):325-331. doi: 10.24171/j.phrp.2017.8.5.06. Epub 2017 Oct 31.

DOI:10.24171/j.phrp.2017.8.5.06
PMID:29164044
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5678197/
Abstract

OBJECTIVES

Studies on are rare in Korea. We investigated the epidemiological characteristics of isolates from patients with -associated disease (CDAD) in Korea.

METHODS

Multiplex polymerase chain reaction was performed to detect the presence of and toxin genes. Antimicrobial susceptibility test was carried out by the disk-dilution method. strains were subtyped by automated repetitive-element palindromic PCR (rep-PCR).

RESULTS

Among patients with CDAD, 73 (25.8%), 32 (11.3%), 32 (11.3%), and 26 (9.2%) suffered from pneumonia, cancer or neoplasm, diabetes, and colitis, respectively. Of all stool samples, 43 samples (15.2%) were positive for strains. We observed two expression patterns of toxin genes: +/+ (86% isolates) and -/+ (14% isolates), with all isolates expressing . Furthermore, some isolates were resistant to clindamycin (65%), ampicillin (56%), and cefazolin (40%), but all were susceptible to vancomycin and metronidazole. The tested samples were classified into diverse clusters using automated rep-PCR.

CONCLUSION

Our findings revealed the characteristics and antibiotic resistance of isolates from patients in Korea. The epidemiological data may provide valuable insight into development of treatment strategies for infections in Korea.

摘要

目的

在韩国，关于[相关内容缺失]的研究很少见。我们调查了韩国艰难梭菌相关性疾病（CDAD）患者分离出的[相关内容缺失]的流行病学特征。

方法

采用多重聚合酶链反应检测[相关内容缺失]和[相关内容缺失]毒素基因的存在情况。通过纸片扩散法进行药敏试验。采用自动重复元件回文PCR（rep-PCR）对[相关内容缺失]菌株进行亚型分型。

结果

在CDAD患者中，分别有73例（25.8%）、32例（11.3%）、32例（11.3%）和26例（9.2%）患有肺炎、癌症或肿瘤、糖尿病和结肠炎。在所有粪便样本中，43份样本（15.2%）[相关内容缺失]菌株呈阳性。我们观察到毒素基因的两种表达模式：+/+（86%的分离株）和-/+（14%的分离株），所有分离株均表达[相关内容缺失]。此外，一些分离株对克林霉素（65%）、氨苄西林（56%）和头孢唑林（40%）耐药，但对万古霉素和甲硝唑均敏感。使用自动rep-PCR将检测样本分为不同的簇。

结论

我们的研究结果揭示了韩国患者分离出的[相关内容缺失]的特征和抗生素耐药性。这些流行病学数据可能为韩国[相关内容缺失]感染治疗策略的制定提供有价值的见解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e9f6/5678197/e95b8c6c6e0c/phrp-08-325f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e9f6/5678197/2169dad3b160/phrp-08-325f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e9f6/5678197/e95b8c6c6e0c/phrp-08-325f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e9f6/5678197/2169dad3b160/phrp-08-325f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e9f6/5678197/e95b8c6c6e0c/phrp-08-325f2.jpg

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