Nubile G, D'Alonzo L, Di Gregorio M, Izzi L
Department of Pathology, S. Massimo Hospital, Penne, Italy.
Am J Clin Pathol. 1989 Feb;91(2):196-8. doi: 10.1093/ajcp/91.2.196.
In this study, the authors wanted to investigate the volume, density, and percentage of three platelet subpopulations present in adult and geriatric males. Ninety subjects, between the ages of 20 and 40, were chosen for the adult group and 50 subjects, all older than age 70, were used for the geriatric group. The platelet subpopulations were separated with discontinuous gradients of Percoll. The results obtained from the three platelet subpopulations--low, intermediate, and high density--show different volumes and percentages in both the groups studied. From the information that larger platelets can be expected to have a longer life span, it was possible to hypothesize that platelets found in geriatric males have a reduced average life span. It is also clear that platelets exist that have similar volumes but different densities.
在本研究中，作者想要调查成年男性和老年男性体内三种血小板亚群的体积、密度和百分比。成年组选取了90名年龄在20至40岁之间的受试者，老年组使用了50名年龄均超过70岁的受试者。血小板亚群通过不连续的Percoll梯度进行分离。从低密度、中密度和高密度这三种血小板亚群获得的结果显示，在两个研究组中它们的体积和百分比各不相同。根据较大的血小板可能具有更长寿命这一信息，可以推测老年男性体内的血小板平均寿命缩短。同样明显的是，存在体积相似但密度不同的血小板。
