自闭症谱系障碍患者血清中期因子水平升高。
Increased serum midkine levels in autism spectrum disorder patients.
作者信息
Esnafoglu Erman, Cirrik Selma
机构信息
a Department of Child and Adolescent Psychiatry, Faculty of Medicine, Research and Training Hospital , Ordu University , Ordu , Turkey.
b Department of Physiology, Faculty of Medicine , Ordu University , Ordu , Turkey.
出版信息
Int J Neurosci. 2018 Jul;128(7):677-681. doi: 10.1080/00207454.2017.1408620. Epub 2017 Dec 6.
BACKGROUND
Midkine (MK) is a heparin binding growth factor and is involved in neurogenesis, neural development and neuroprotection. Additionally, MK may contribute to cancer development and pathogenesis of neurodegenerative disorders and schizophrenia. Considering these effects of MK, this study researched whether MK is involved in autism spectrum disorders (ASD) pathogenesis.
METHODS
We evaluated serum MK levels of 38 patients with ASD and 32 healthy control group. MK levels were measured with ELISA, while ASD severity was assessed with Childhood Autism Rating Scale.
RESULTS
Our data showed that the serum MK concentration in ASD patients (mean ± SD, 11.51 ± 8.53 pg/ml) is significantly higher than healthy controls (mean ± SD, 6.19 ± 3.94 pg/ml) (p = 0.007).
CONCLUSIONS
According to these results, MK may play a role in ASD pathogenesis.
背景
中期因子（MK）是一种肝素结合生长因子，参与神经发生、神经发育和神经保护。此外，MK可能与癌症发展以及神经退行性疾病和精神分裂症的发病机制有关。考虑到MK的这些作用，本研究探讨了MK是否参与自闭症谱系障碍（ASD）的发病机制。
方法
我们评估了38例ASD患者和32例健康对照组的血清MK水平。采用酶联免疫吸附测定法（ELISA）测量MK水平，同时用儿童自闭症评定量表评估ASD严重程度。
结果
我们的数据显示，ASD患者的血清MK浓度（均值±标准差，11.51±8.53 pg/ml）显著高于健康对照组（均值±标准差，6.19±3.94 pg/ml）（p = 0.007）。
结论
根据这些结果，MK可能在ASD发病机制中起作用。
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