Kiss A, Haubenstock A, Bognar H, Scheiderbauer R, al-Mobarak M, Base W
Department of Medicine I, University of Vienna, Austria.
Am J Hematol. 1989 Mar;30(3):188-9. doi: 10.1002/ajh.2830300313.
A patient with prolymphocytic leukemia (PLL), a lymphoproliferative disorder that carries a poor prognosis, is presented. The disease was diagnosed at an early stage and treatment could be delayed for four years. When massive, painful splenomegaly developed, splenic irradiation (SI) was chosen as the primary form of therapy and an excellent systemic response could be achieved. Our observation is in agreement with preliminary studies, which advocate SI as the primary form of therapy in PLL. Furthermore, it is emphasized that an early diagnosis of PLL is necessary to establish its true course and that the prognosis may be better than originally thought.
本文介绍了一名患有幼淋巴细胞白血病（PLL）的患者，这是一种预后较差的淋巴细胞增殖性疾病。该疾病在早期被诊断出来，治疗被推迟了四年。当出现巨大、疼痛性脾肿大时，选择脾照射（SI）作为主要治疗方式，并取得了良好的全身反应。我们的观察结果与初步研究一致，初步研究主张将SI作为PLL的主要治疗方式。此外，强调对PLL进行早期诊断对于确定其真实病程是必要的，并且其预后可能比最初认为的要好。
