Osborne P T, Burkett L L, Ryan G M, Lane M
Department of Pathology, College of Medicine, University of Tennessee, Memphis.
Am J Obstet Gynecol. 1989 Feb;160(2):336-9. doi: 10.1016/0002-9378(89)90438-9.
A new classification of anemias, which is based on mean corpuscular volume and quantitative anisocytosis (red blood cell distribution width), was evaluated in 331 pregnant women on initial presentation for prenatal care. Seventy-four of them had severe iron depletion (serum ferritin level less than or equal to 10 ng/dl). Contrary to the above classification, early iron deficiency without anemia was infrequently identified by an increase in distribution width (4 of 25 patients). The distribution width was not consistently increased in the 49 anemic, iron-deficient patients; 34 were normal and would have been considered to have thalassemia minor or anemia of chronic disease according to the new classification. The distribution width was no more sensitive than the mean corpuscular volume in suggesting iron deficiency. This study does not confirm the usefulness of the new classification in the diagnosis of iron deficiency in this patient population.
一种基于平均红细胞体积和定量红细胞大小不均一性（红细胞分布宽度）的贫血新分类方法，在331名首次前来接受产前检查的孕妇中进行了评估。其中74人有严重铁缺乏（血清铁蛋白水平小于或等于10 ng/dl）。与上述分类相反，分布宽度增加很少能识别出无贫血的早期缺铁（25例患者中有4例）。在49例贫血且缺铁的患者中，分布宽度并非持续增加；34例正常，根据新分类本会被认为患有轻型地中海贫血或慢性病性贫血。在提示缺铁方面，分布宽度并不比平均红细胞体积更敏感。本研究未证实该新分类在诊断该患者群体缺铁方面的有用性。
