肺肿瘤和贲门癌共同分泌胰岛素导致低血糖：首例病例报告。
Hypoglycemia caused by co-secretion of insulin from lung tumor and cardia cancer: first case report.
作者信息
Chen Yaning, Kang Yi, Hong Liu, Yao Hebin
机构信息
Attending Physician, Department of Endocrinology, General Navy Hospital of PLA, Beijing, China.
MD. Professor, Department of Endocrinology, General Navy Hospital of PLA, Beijing, China.
出版信息
Sao Paulo Med J. 2019 Jan-Feb;137(1):100-103. doi: 10.1590/1516-3180.2017.0136060617. Epub 2017 Nov 17.
CONTEXT
Non-islet-cell-tumor-induced hypoglycemia (NICTH) is caused on rare occasions by secretion of insulin from tumor cells that are reported to have a single tissue origin.
CASE REPORT
A 67-year-old male patient had cardia adenocarcinoma and concomitant lung adenocarcinoma with extensive metastases and repeated episodes of intractable hypoglycemia. Immunohistochemical staining for insulin showed that lung adenocarcinoma stained positive and gastric cardia adenocarcinoma stained weakly positive. These results indicate that tumor cells of different tissue origins co-secreted insulin.
CONCLUSIONS
This is the first report on intractable hypoglycemia due to co-secretion of insulin from two kinds of primary tumor cells in a single patient.
背景
非胰岛细胞瘤所致低血糖症（NICTH）在极少数情况下由肿瘤细胞分泌胰岛素引起，据报道这些肿瘤细胞具有单一组织来源。
病例报告
一名67岁男性患者患有贲门腺癌并伴有广泛转移的肺腺癌，且反复出现顽固性低血糖症。胰岛素免疫组化染色显示肺腺癌呈阳性，胃贲门腺癌呈弱阳性。这些结果表明不同组织来源的肿瘤细胞共同分泌胰岛素。
结论
本文首次报道了一名患者因两种原发性肿瘤细胞共同分泌胰岛素导致顽固性低血糖症。
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