Feld L G, Noble B, Springate J E, Feldman M J, Van Liew J B
Department of Microbiology, State University of New York, Buffalo.
Am J Physiol. 1989 Feb;256(2 Pt 2):F224-8. doi: 10.1152/ajprenal.1989.256.2.F224.
We examined the influence of a low-protein diet on the course of the renal injury in spontaneously hypertensive rats (SHR) and SHR given antihypertensive drug therapy (SHRD). Antihypertensive drug treatment was hydralazine, reserpine, and chlorothiazide. Wistar-Kyoto (WKY) rats served as normotensive controls. SHR, SHRD, and WKY were each placed on a 24, 14, and 10% protein diet at 5 wk and followed to 80-90 wk of age. Untreated SHR showed a steady rise in protein excretion from 5 to 70 wk regardless of dietary protein content. Protein excretion in SHRD on a 24% protein diet was similar to untreated SHR. However, SHRD on a 14 or 10% diet had a more moderate increase in protein excretion. Glomerular, tubular, and vascular pathology in untreated SHR was not influenced by dietary protein intake. Despite successful antihypertensive therapy, kidney pathology in SHRD on a 24% diet was not significantly different from untreated SHR. In contrast, SHRD on 14 or 10% protein diets had less segmental glomerulosclerosis and vascular pathology than untreated SHR. The results indicate that dietary protein restriction does not influence the course of renal injury in untreated SHR. However, the combination of antihypertensive drug therapy with protein restriction in SHR delays and may arrest progression of glomerulosclerosis and proteinuria.
我们研究了低蛋白饮食对自发性高血压大鼠（SHR）以及接受抗高血压药物治疗的SHR（SHRD）肾损伤病程的影响。抗高血压药物治疗采用肼屈嗪、利血平和氯噻嗪。Wistar-Kyoto（WKY）大鼠作为血压正常的对照。SHR、SHRD和WKY在5周龄时分别给予24%、14%和10%的蛋白质饮食，并追踪至80 - 90周龄。未经治疗的SHR无论饮食蛋白质含量如何，其蛋白质排泄量从5周龄到70周龄均呈稳步上升。接受24%蛋白质饮食的SHRD的蛋白质排泄情况与未经治疗的SHR相似。然而，接受14%或10%饮食的SHRD的蛋白质排泄量增加较为适度。未经治疗的SHR的肾小球、肾小管和血管病理情况不受饮食蛋白质摄入量的影响。尽管抗高血压治疗取得成功，但接受24%饮食的SHRD的肾脏病理与未经治疗的SHR并无显著差异。相比之下，接受14%或10%蛋白质饮食的SHRD的节段性肾小球硬化和血管病理情况比未经治疗的SHR要轻。结果表明，饮食蛋白质限制不会影响未经治疗的SHR的肾损伤病程。然而，SHR中抗高血压药物治疗与蛋白质限制相结合可延缓并可能阻止肾小球硬化和蛋白尿的进展。
