T 细胞受体承担部分免疫责任。
The TCR Takes Some Immune Responsibility.
机构信息
Department of Pathology and Immunology, Washington University, St. Louis, MO 63110, USA.
Department of Pathology and Immunology, Washington University, St. Louis, MO 63110, USA.
出版信息
Immunity. 2017 Nov 21;47(5):803-804. doi: 10.1016/j.immuni.2017.10.018.
Abstract
In this issue of Immunity, Van Braeckel-Budimmir et al. (2017) reveal that the pathogenic response of mice to a Plasmodium berghei infection is dominated by a Vβ8.1 T cell response. Mice lacking Vβ8.1 T cells fail to mount a pathogenic response, thus showing that the TCR locus can be an Immune response (Ir) gene.
摘要
在本期《免疫》中，Van Braeckel-Budimmir 等人（2017 年）揭示了小鼠对疟原虫伯氏疟原虫感染的致病反应主要由 Vβ8.1 T 细胞反应主导。缺乏 Vβ8.1 T 细胞的小鼠无法引发致病反应，因此表明 TCR 基因座可以成为免疫反应（Ir）基因。
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