Student Research committee, Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Cancer research center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Eur J Clin Nutr. 2018 Mar;72(3):394-400. doi: 10.1038/s41430-017-0022-9. Epub 2017 Nov 23.
BACKGROUND/OBJECTIVES: This study was aimed to investigate the association of maternal serum and breast-milk levels of macronutrients, hormones, growth factors, and maternal body composition with infant's body weight.
SUBJECTS/METHODS: Eighty mother-infant pairs comprised 40 with overweight or obese infant and 40 with normal-weight infant were enrolled in this study. The level of ghrelin, Leptin, adiponectin, EGF, and IGF1 in plasma and breast milk were assessed. Daily breast milk intake and macronutrient concentration along with anthropometric indices of mother-infant pairs were also assessed.
No significant differences were observed in concentrations of serum hormones between two groups (p > 0.05). However, hormones levels in maternal serum were higher than those in breast milk. A significant positive correlation was found between serum EGF and ghrelin (r = 0.57, p = 0 < 0001). Higher IGF1 in serum showed a significant association with its milk counterpart (r = 0.37). Current mother's weight was associated with infant's weight at the 2nd and 6th month (B = 0.023 p = 0.04, B = 0.055 p = 0.005). The breast-milk macronutrient content was not comparable between two groups. However, the average daily breast milk consumption in obese infants was higher than normals (p = 0.001). Milk EGF and leptin were related to a decrease of 59% and 46% the odds of obese infant development, respectively. There was a significant association of milk EGF and ghrelin with birth weight (B = -0.19, p = 0.04 and B = -0.2, p = 0.04, respectively), and also serum leptin with infant's body weight at the 6th month.
Our findings provide a positive association of maternal weight, daily breast milk intake, EGF, and ghrelin with infant's body weight.
背景/目的：本研究旨在探讨母体血清和母乳中宏量营养素、激素、生长因子和母体身体成分与婴儿体重的关系。
本研究纳入了 80 对母婴，其中 40 对婴儿超重或肥胖，40 对婴儿体重正常。评估了血浆和母乳中胃饥饿素、瘦素、脂联素、EGF 和 IGF1 的水平。还评估了母婴每日母乳摄入量和宏量营养素浓度以及母婴的人体测量指数。
两组间血清激素浓度无显著差异（p>0.05）。然而，母体血清中的激素水平高于母乳中的水平。血清 EGF 和胃饥饿素呈显著正相关（r=0.57，p<0.0001）。血清 IGF1 水平较高与母乳中 IGF1 水平呈显著正相关（r=0.37）。当前母亲的体重与婴儿在第 2 个月和第 6 个月的体重呈正相关（B=0.023，p=0.04；B=0.055，p=0.005）。两组间母乳宏量营养素含量无差异。然而，肥胖婴儿的平均每日母乳摄入量高于正常婴儿（p=0.001）。牛奶 EGF 和瘦素与肥胖婴儿发生的几率分别降低 59%和 46%有关。牛奶 EGF 和胃饥饿素与出生体重呈显著负相关（B=-0.19，p=0.04 和 B=-0.2，p=0.04），血清瘦素与婴儿在第 6 个月的体重也呈显著负相关。
我们的研究结果提供了母体体重、每日母乳摄入量、EGF 和胃饥饿素与婴儿体重之间的正相关关系。
