Harioudh Munesh Kumar, Sahai Rohit, Mitra Kalyan, Ghosh Jimut Kanti
Molecular and Structural Biology Division, CSIR-Central Drug Research Institute, Lucknow-226031, Uttar Pradesh, India.
Chem Commun (Camb). 2017 Dec 5;53(97):13079-13082. doi: 10.1039/c7cc07547b.
Aβ residues with tryptophan in place of the lone methionine residue and three arginine residues added to its C-terminus exhibited augmented antibacterial activities and protected mice against a lethal dose of LPS. The results show the conversion of a Aβ segment into a cell-selective antimicrobial/anti-endotoxin peptide with nanostructure and cation-π interaction.
用色氨酸取代单个甲硫氨酸残基并在其C末端添加三个精氨酸残基的Aβ残基表现出增强的抗菌活性，并保护小鼠免受致死剂量的脂多糖侵害。结果表明，一个Aβ片段转化为具有纳米结构和阳离子-π相互作用的细胞选择性抗菌/抗内毒素肽。
