人类皮肤微生物组失调促进特应性皮炎的证据。
Evidence that Human Skin Microbiome Dysbiosis Promotes Atopic Dermatitis.
机构信息
Department of Dermatology, University of California, San Diego, California, USA.
Department of Dermatology, University of California, San Diego, California, USA.
出版信息
J Invest Dermatol. 2017 Dec;137(12):2460-2461. doi: 10.1016/j.jid.2017.09.010.
Abstract
Patients with atopic dermatitis are frequently colonized by Staphylococcus aureus. If S. aureus is present, then the subject tends to have more severe disease. However, it is unclear if S. aureus is a cause of atopic dermatitis or a consequence of the abnormal epithelial environment. In this issue of the Journal of Investigative Dermatology, Meylan et al. present evidence from a prospective clinical trial that shows that S. aureus colonization precedes onset of atopic dermatitis in children. These observations suggest that S. aureus may cause atopic dermatitis in some individuals.
摘要
特应性皮炎患者常定植有金黄色葡萄球菌。如果金黄色葡萄球菌存在，那么患者的疾病往往更严重。然而，目前尚不清楚金黄色葡萄球菌是特应性皮炎的病因还是异常上皮环境的后果。在本期《皮肤病学研究杂志》上，Meylan 等人提供了一项前瞻性临床试验的证据，表明金黄色葡萄球菌定植先于儿童特应性皮炎发病。这些观察结果表明金黄色葡萄球菌可能在某些个体中引起特应性皮炎。
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Skin Colonization by Staphylococcus aureus Precedes the Clinical Diagnosis of Atopic Dermatitis in Infancy.金黄色葡萄球菌皮肤定植先于婴儿期特应性皮炎的临床诊断。
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Antimicrobials from human skin commensal bacteria protect against and are deficient in atopic dermatitis.来自人体皮肤共生菌的抗菌物质可预防特应性皮炎，且特应性皮炎患者体内这些抗菌物质不足。
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