Hosseini Mahmoud, Beheshti Farimah, Sohrabi Farzaneh, Vafaee Farzaneh, Shafei Mohammad Naser, Reza Sadeghnia Hamid
a Division of Neurocognitive Sciences, Psychiatry and Behavioral Sciences Research Center , Mashhad University of Medical Sciences , Mashhad , Iran.
b Neurogenic Inflammation Research Center , Mashhad University of Medical Sciences , Iran.
J Diet Suppl. 2018 Sep 3;15(5):715-727. doi: 10.1080/19390211.2017.1386749. Epub 2017 Nov 27.
We investigated the effects of feeding vitamin C (Vit C) during neonatal and juvenile growth on learning and memory of rats. Rats after delivery were randomly divided into four groups and treated. Group 1, control group, received normal drinking water. Groups 2-4 received Vit C 10, 100, and 500 mg/kg, respectively, from the first day. After 8 weeks, 10 male offspring of each group were randomly selected and tested in the Morris water maze (MWM) and passive avoidance (PA) tests. Finally, the brains were removed for biochemical measurement. In MWM, 10-500 mg/kg Vit C reduced the latency and traveled distance and increased time spent in the target quadrant. In PA, 10 and 100 mg/kg of Vit C increased the latency; 10-500 mg/kg of Vit C decreased the malondialdehyde (MDA) in the brain tissues and increased thiol and catalase (CAT) activity compared to the control group. We showed that feeding rats Vit C during neonatal and juvenile growth has positive effects on learning and memory.
我们研究了在新生和幼年生长阶段喂食维生素C（Vit C）对大鼠学习和记忆的影响。分娩后的大鼠被随机分为四组并进行处理。第1组为对照组，给予正常饮用水。第2 - 4组从第一天起分别给予10、100和500 mg/kg的Vit C。8周后，每组随机选取10只雄性后代，在莫里斯水迷宫（MWM）和被动回避（PA）试验中进行测试。最后，取出大脑进行生化测量。在MWM中，10 - 500 mg/kg的Vit C缩短了潜伏期和游动距离，并增加了在目标象限的停留时间。在PA中，10和100 mg/kg的Vit C增加了潜伏期；与对照组相比，10 - 500 mg/kg的Vit C降低了脑组织中的丙二醛（MDA）含量，并提高了硫醇和过氧化氢酶（CAT）的活性。我们表明，在新生和幼年生长阶段给大鼠喂食Vit C对学习和记忆有积极影响。
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