利用微粒子诱导 X 射线发射评估 SiC 纳米气溶胶的快速、非对称和非均相清除。
Fast, asymmetric and nonhomogeneous clearance of SiC nanoaerosol assessed by micro-particle-induced x-ray emission.
机构信息
Research Centre for the Physics of Matter & Radiation (PMR), Namur Nanosafety Center (NNC), NAmur Research Institute for LIfe Sciences (NARILIS), University of Namur (UNamur), B-5000 Namur, Belgium.
Cátedra de Cardiología y Medicina Vascular, Escuela de Medicina y Ciencias de la Salud, Tecnologico de Monterrey, 64849 Monterrey, México.
出版信息
Nanomedicine (Lond). 2018 Jan;13(2):145-155. doi: 10.2217/nnm-2017-0245. Epub 2017 Nov 27.
AIM
To study the biopersistence of a silicon carbide (SiC) nanoaerosol in rat lungs, as time-dependent clearance and spatial distribution.
MATERIALS & METHODS: Sprague-Dawley rats were exposed 6 h/day during 5 days to a SiC nanoaerosol at 4.91 mg SiC/l. SiC biopersistence in rat lungs sections was assessed over 28 days by micro-particle-induced x-ray emission (μPIXE) as 2D maps and by particle-induced x-ray emission (PIXE) for whole-lung quantification. 2D maps were analyzed for SiC spatial distribution as skewness and kurtosis.
RESULTS
Half-time clearance was 10.9 ± 0.9 days, agreeing with PIXE measurements. Spatial-temporal analysis of SiC indicated decreased symmetry and homogeneity.
CONCLUSION
Fast SiC clearance points that current nanoaerosol exposure may not be enough to trigger lung overload. Spatial distribution shows an asymmetric and nonhomogeneous SiC clearance.
目的
研究碳化硅（SiC）纳米气溶胶在大鼠肺部的生物持久性，以及随时间的清除和空间分布情况。
材料与方法
Sprague-Dawley 大鼠在 5 天内每天暴露于 4.91mg SiC/l 的 SiC 纳米气溶胶中 6 小时。通过微粒子诱导 X 射线发射（μPIXE）作为 2D 图谱和通过粒子诱导 X 射线发射（PIXE）对整个肺进行定量，在 28 天内评估 SiC 在大鼠肺组织切片中的生物持久性。通过偏度和峰度分析 2D 图谱来评估 SiC 的空间分布。
结果
清除半衰期为 10.9±0.9 天，与 PIXE 测量结果一致。SiC 的时空分析表明对称性和均一性降低。
结论
SiC 快速清除表明目前的纳米气溶胶暴露可能不足以引发肺过载。空间分布显示 SiC 清除呈非对称和非均相。
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