子宫平滑肌瘤细胞遗传学。I. 12号染色体重排。

Uterine leiomyoma cytogenetics. I. Rearrangements of chromosome 12.

作者信息

Vanni R, Nieddu M, Paoli R, Lecca U

机构信息

Istituto di Biologia Generale, Universita degli Studi, Cagliari, Italy.

出版信息

Cancer Genet Cytogenet. 1989 Jan;37(1):49-54. doi: 10.1016/0165-4608(89)90073-3.

DOI:10.1016/0165-4608(89)90073-3

PMID:2917332

Abstract

Cytogenetic investigation on 19 benign tumors of uterine smooth muscle was carried out after short-term cultures. Clonal chromosome abnormalities were present in four cases; 15 had normal karyotypes. All four cases with abnormal karyotype showed changes of chromosome 12. In three cases, chromosome 12 was involved in structural rearrangements with chromosome X, 1, and 4, respectively. Breakpoints on this chromosome occurred in different regions. The fourth case had trisomy 12 and an extra deleted chromosome 2, del(2)(p22). These findings confirm the involvement of chromosome 12 in uterine leiomyoma.

摘要

对19例子宫平滑肌良性肿瘤进行了短期培养后的细胞遗传学研究。4例存在克隆性染色体异常；15例核型正常。所有4例核型异常的病例均显示12号染色体有改变。其中3例中，12号染色体分别与X、1和4号染色体发生了结构重排。该染色体上的断点出现在不同区域。第4例有12号染色体三体和一条额外的2号染色体缺失，即del(2)(p22)。这些发现证实了12号染色体与子宫平滑肌瘤有关。