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骨质疏松症与遗传

Osteoporosis and heredity.

作者信息

Gärdsell P, Lindberg H, Obrant K J

机构信息

Department of Orthopaedic Surgery, Malmö General Hospital, University of Lund, Sweden.

出版信息

Clin Orthop Relat Res. 1989 Mar(240):164-7.

PMID:2917430
Abstract

A retrospective epidemiological study was performed to determine whether postmenopausal osteoporosis is a hereditary condition. Frequency of fractures was calculated in women whose mothers had suffered vertebral fractures after a low-energy trauma three decades earlier. The frequency of fractures was compared to the frequency in an age-matched control group. The daughters of the osteoporotic women were not more prone to sustain fractures than the controls.

摘要

进行了一项回顾性流行病学研究,以确定绝经后骨质疏松症是否为遗传性疾病。计算了母亲在三十年前因低能量创伤而发生椎体骨折的女性的骨折发生率。将骨折发生率与年龄匹配的对照组的发生率进行比较。骨质疏松症女性的女儿并不比对照组更容易发生骨折。

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引用本文的文献

1
Fracture of the upper end of the femur is not associated with familial fracture disposition.
Arch Orthop Trauma Surg. 1989;108(5):265-7. doi: 10.1007/BF00932310.
2
Increasing age-adjusted risk of fragility fractures: a sign of increasing osteoporosis in successive generations?年龄调整后的脆性骨折风险增加:这是几代人骨质疏松症增加的迹象吗?
Calcif Tissue Int. 1989 Mar;44(3):157-67. doi: 10.1007/BF02556558.
3
Osteoporosis: the evolution of a scientific term.
Osteoporos Int. 1992 Jul;2(4):164-7. doi: 10.1007/BF01623921.