Department of Molecular Oncology, Eastern Hepatobiliary Surgical Hospital & National Center of Liver Cancer, Second Military Medical University, Shanghai, 200438, China.
Department of Molecular Oncology, Eastern Hepatobiliary Surgical Hospital & National Center of Liver Cancer, Second Military Medical University, Shanghai, 200438, China.
Cancer Lett. 2018 Feb 1;414:222-229. doi: 10.1016/j.canlet.2017.11.024. Epub 2017 Nov 23.
Protein phosphatase 2, regulatory subunit B (B56), alpha isoform (PPP2R5A) is one of the regulatory subunits of the protein phosphatase 2A (PP2A), which is a major member of protein serine/threonine phosphatases in cells. PPP2R5A can regulate the cellular location, substrate specification and protein phosphatase function of PP2A, through which PPP2R5A plays an important role in many cellular activities. It has been reported that PPP2R5A relates with many diseases including some kinds of cancers, but the related mechanisms have a lot remaining to be discovered or demonstrated. This review arms to summarize PPP2R5A and its relationships with the occurrence and progression of tumors, helping us to further understand its significance in the prevention, early diagnosis, targeted therapy and prognosis improvement of tumors.
蛋白磷酸酶 2A 的调节亚基 B 型（B56），α 同工型（PPP2R5A）是蛋白磷酸酶 2A（PP2A）的调节亚基之一，它是细胞中蛋白丝氨酸/苏氨酸磷酸酶的主要成员。PPP2R5A 可以通过调节 PP2A 的细胞定位、底物特异性和蛋白磷酸酶功能来发挥作用，从而在许多细胞活动中发挥重要作用。已有报道称 PPP2R5A 与包括某些癌症在内的多种疾病有关，但相关机制仍有许多有待发现或证实。本综述旨在总结 PPP2R5A 及其与肿瘤发生和发展的关系，帮助我们进一步了解其在肿瘤的预防、早期诊断、靶向治疗和预后改善中的意义。
