Pino A, Maura A, Grillo P
Istituto di Farmacologia dell'Università, Genova, Italy.
Environ Mol Mutagen. 1989;13(2):112-5. doi: 10.1002/em.2850130205.
The mutagenic and DNA-damaging activities of cinoxacin were evaluated in the rat granuloma pouch assay (GPA) in order to assess its genotoxic potential in vivo. High doses of this antimicrobial quinolone, either directly injected into the pouch or administered by gavage, did not induce mutation at the hgprt locus or DNA fragmentation in granuloma cells. Moreover, DNA damage was absent in the liver and kidney of rats given cinoxacin by the oral route.
为了评估西诺沙星在体内的遗传毒性潜力，在大鼠肉芽肿袋试验（GPA）中对其致突变和DNA损伤活性进行了评估。高剂量的这种抗菌喹诺酮类药物，无论是直接注射到袋中还是通过灌胃给药，均未在次黄嘌呤-鸟嘌呤磷酸核糖转移酶（HGPRT）位点诱导突变，也未在肉芽肿细胞中诱导DNA片段化。此外，口服西诺沙星的大鼠肝脏和肾脏中未出现DNA损伤。
